Capozide is captopril and hydrochlorothiazide.
Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.
- TRADE NAMES: Acenorm; Acepril; Adocor; APO-Capto; Capoten (Par); Capozide (Par); Captolane; Captoril; Lopirin; Lopril; Nu-Capto; Precaptil
- INDICATIONS: Hypertension, congestive heart failure, to improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction, diabetic nephropathy in patients with Type I insulin-dependent diabetes mellitus and retinopathy
- CLASS: Angiotensin-converting enzyme (ACE) inhibitor, Antihypertensive, Vasodilator
- HALF-LIFE: <3 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Aldesleukin, Allopurinol, Alpha blockers, Alprostadil, Amifostine, Amiloride, Angiotensin II receptor antagonists, Antacids, Antidiabetics, Antihypertensives, Antipsychotics, Anxiolytics and hypnotics, Aprotinin, Azathioprine, Baclofen, Beta blockers, Calcium channel blockers, Clonidine, Cyclosporine, CYP2D6 inhibitors, Darunavir, Diazoxide, Digoxin, Diuretics, Eplerenone, Estrogens, Everolimus, General anesthetics, Gold & Gold Compounds, Heparins, Herbals, Hydralazine, Hypotensives, Insulin, Interferon Alfa, Levodopa, Lithium, MAO inhibitors, Metformin, Methyldopa, Methylphenidate, Minoxidil, Moxisylyte, Moxonidine, Naldemedine, Nitrates, Nitroprusside, NSAIDs, Pentoxifylline, Phosphodiesterase 5 inhibitors, Potassium salts, Probenecid, Prostacyclin analogues, Rituximab, Salicylates, Sirolimus, Spironolactone, Sulfonylureas, Temsirolimus, Tizanidine, Tolvaptan, Triamterene, Trimethoprim, Venetoclax, Yohimbine - PREGNANCY: category C in first trimester; category D in second and third trimesters
- See adverse reactions attributed to class:
FETAL TOXICITY
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Page last updated 11/10/2023
