Baclofen

Pediatric
  • TRADE NAMES: Baclofen (Watson); Baclon; Baclosal; Baklofen; Clofen; Dom-Baclofen; Gablofen (Mallinckrodt); Gen-Baclofen; Lebic; Lioresal (Medtronic); Nu-Baclo; Pacifen; PMS-Baclofen; Spinax
  • INDICATIONS: Spasticity resulting from multiple sclerosis
  • CLASS: GABA receptor agonist, Skeletal muscle relaxant
  • HALF-LIFE: 2.5–4 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Acebutolol, Alcohol, Alfuzosin, Amitriptyline, Captopril, Cilazapril, Diclofenac, Enalapril, Fosinopril, Irbesartan, Levodopa, Lisinopril, Meloxicam, Olmesartan, Quinapril, Ramipril, Trandolapril

PREGNANCY CATEGORY: C

Children appear to be at higher risk for complications than adults when using intrathecal baclofen (ITB). ITB therapy is a safe and effective treatment for severe spasticity in the pediatric population, but does have a 31% rate of complications requiring surgical management over a 3-year treatment period.

DO NOT DISCONTINUE ABRUPTLY

See full prescribing information for complete boxed warning.

Our database has 53 adverse reactions for this drug across the following areas

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SKIN.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
LOCAL.
NEUROMUSCULAR/SKELETAL.
OCULAR.
OTIC.
RESPIRATORY.
OTHER.


Page last updated 09/19/2023

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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