Diclofenac drug interactions | Litt's Drug Eruption and Reaction Database

Diclofenac comment watch save

TRADE NAMES: Allvoran; Apo-Diclo; Arthrotec (Pfizer); Cambia; Cataflam (Novartis); Dicolmax (Galen); Dyloject; Fenac; Flector Patch; Galedol; Liroken; Monoflam; Motifene (Daiichi Sankyo); Nu-Diclo; Pennsaid (Mallinckrodt); Remethan; Solaraze Gel (Nycomed); Taks; Voltaren (Novartis); Voltarene; Voltarol (Novartis); Zipsor (Depomed); Zorvolex
INDICATIONS: Rheumatoid and osteoarthritis, topical treatment of actinic keratosis; postoperative inflammation in patients who have undergone cataract extraction and for the temporary relief of pain and photophobia in patients undergoing corneal refractive surgery
CLASS: Non-steroidal anti-inflammatory (NSAID)
HALF-LIFE: 1–2 hours

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
ACE inhibitors, Adrenergic neurone blockers, Aldosterone antagonists, Aliskiren, Alpha blockers, Angiotensin II receptor antagonists, Anticoagulants, Aspirin, Baclofen, Beta blockers, Calcium channel blockers, Cardiac glycosides, Clonidine, Clopidogrel, Corticosteroids, Coumarins, Cyclosporine, Dabigatran, Deferiprone, Diazoxide, Diuretics, Enoxaparin, Erlotinib, Furosemide, Heparins, Hydralazine, Iloprost, Ketorolac, Lithium, Methotrexate, Methyldopa, Mifamurtide, Minoxidil, Moxonidine, Nitrates, Nitroprusside, Penicillamine, Pentoxifylline, Phenindione, Potassium canrenoate, Prasugrel, Rifampin, Ritonavir, Rivaroxaban, SSRIs, Sulfonylureas, Tacrolimus, Thiazides, Tinzaparin, Venlafaxine, Voriconazole, Warfarin, Zidovudine
PREGNANCY: category B for topical use; category C for oral and ophthalmic use; category D in third trimester.

See adverse reactions attributed to class:
Non-steroidal anti-inflammatory (NSAID)

NSAIDs may cause an increased risk of serious cardiovascular and gastrointestinal adverse events, which can be fatal. This risk may increase with duration of use.

Contra-indicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.

Arthrotec is diclofenac and misoprostol.

RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS

See full prescribing information for complete boxed warning.

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DRUG REVIEW ARTICLE

Click on the DRUG REVIEW ARTICLE tab (above) to see a review of low-dose diclofenac in the Taylor & Francis journal Expert Opinion on Drug Safety.

(Note that non-subscribers to the journal will only be able to see an abstract of the article.)

Page last updated 04/18/2025

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Incidence

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Seriousness

Hospitalization possible
Life threatening
Fatal

Warnings in other populations

Breast feeding

Geriatric

Pediatric