Enoxaparin

BreastfeedingPediatric
  • TRADE NAMES: Clexane (Sanofi-Aventis); Klexane; Lovenox (Sanofi-Aventis)
  • INDICATIONS: Prevention of deep vein thrombosis, ischemic complications of unstable angina and non-Q wave myocardial infarction; treatment of acute ST-segment elevation myocardial infarction
  • CLASS: Heparin, low molecular weight
  • HALF-LIFE: 4.5 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

ACE inhibitors, Angiotensin II receptor antagonists, Anticoagulants, Aspirin, Butabarbital, Clopidogrel, Danaparoid, Diclofenac, Dipyridamole, Drotrecogin Alfa, Iloprost, Infused nitrates, Ketorolac, NSAIDs, Platelet inhibitors, Rivaroxaban, Salicylates, Sulfinpyrazone

PREGNANCY CATEGORY: B

Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins or heparinoids and are receiving neuraxial anesthesia or undergoing spinal puncture.

Contra-indicated in patients with active major bleeding; thrombocytopenia with a positive in vitro test for anti-platelet antibody in the presence of enoxaparin; hypersensitivity to heparin or pork products; hypersensitivity to benzyl alcohol (multi-dose formulation only).

SPINAL/EPIDURAL HEMATOMA

See full prescribing information for complete boxed warning.

Our database has 58 adverse reactions for this drug across the following areas

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SKIN.
HAIR.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
LOCAL.
NEUROMUSCULAR/SKELETAL.
RESPIRATORY.
OTHER.


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Click on the DRUG REVIEW ARTICLE tab (above) to see a review of enoxaparin in the Taylor & Francis journal Expert Opinion on Drug Safety. (Note that non-subscribers to the journal will only be able to see an abstract of the article.)

Page last updated 03/20/2020

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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