Penicillamine
- TRADE NAMES: Artamin; D-Penamine; Depen (MedPointe); Distamine; Kelatin; Pendramine
- INDICATIONS: Wilson’s disease, rheumatoid arthritis
- CLASS: Antidote, Chelator, Disease-modifying antirheumatic drug (DMARD)
- HALF-LIFE: 1.7–3.2 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Aluminum, Antacids, Ascorbic Acid, Bone marrow suppressants, Chloroquine, Clozapine, Cytotoxic agents, Diclofenac, Ferrous Sulfate, Food, Gold & Gold Compounds, Hydroxychloroquine, Iron, Magnesium, Meloxicam, Primaquine, Probenecid, Sodium Picosulfate
PREGNANCY CATEGORY: D
In the treatment of Wilson's disease, it is sometimes difficult to differentiate side effects due to the drug from those due to the effects of the disease.
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SKIN.
HAIR.
NAILS.
MUCOSAL.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
RENAL.
RESPIRATORY.
OTHER.
Click on the DRUG REVIEW ARTICLE tab (above) to see a review of D-penicillamine in the Taylor & Francis journal Expert Opinion on Drug Safety. (Note that non-subscribers to the journal will only be able to see an abstract of the article.)
Page last updated 12/16/2023
Symbol key
Incidence
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric