Clozapine
- TRADE NAMES: Clozaril (Novartis); Denzapine (Merz); Entumin; Entumine; FazaClo; Klozapol; Leponex (Novartis); Lozapin; Sizopin; Zaponex (Teva)
- INDICATIONS: Treatment-resistant schizophrenia
- CLASS: Antipsychotic
- HALF-LIFE: 4–12 hours
Alcohol, Amitriptyline, Antimuscarinics, Arsenic, Benzodiazepines, Cabazitaxel, Caffeine, Carbamazepine, Chloramphenicol, Cimetidine, Ciprofloxacin, Citalopram, Cocoa, Cyclophosphamide, Cytotoxics, Darifenacin, Dasatinib, Encainide, Epinephrine, Erythromycin, Everolimus, Flecainide, Fluoxetine, Flupentixol, Fluphenazine, Fluvoxamine, Gefitinib, Guarana, Haloperidol, Insulin Degludec, Insulin Detemir, Insulin Glargine, Insulin Glulisine, Lapatinib, Lithium, Lomustine, Lorazepam, MAO inhibitors, Nilotinib, Norfloxacin, Ofloxacin, Omeprazole, Oxaliplatin, Oxybutynin, Paroxetine Hydrochloride, Pazopanib, Pemetrexed, Penicillamine, Pipotiazine, Propafenone, Quinidine, Rifampin, Risperidone, Ritonavir, Saquinavir, Selenium, Sertraline, Sorafenib, Sulfonamides, Sunitinib, Telithromycin, Temozolomide, Temsirolimus, Tetrazepam, Tricyclic antidepressants, Trospium, Uracil/Tegafur, Valproic Acid, Venlafaxine, Viloxazine, Zuclopenthixol
PREGNANCY CATEGORY: B
Contra-indicated in patients with myeloproliferative disorders, uncontrolled epilepsy, paralytic ileus, or a history of clozapine-induced agranulocytosis or severe granulocytopenia.
AGRANULOCYTOSIS / SEIZURES / MYOCARDITIS / OTHER ADVERSE CARDIOVASCULAR AND RESPIRATORY EFFECTS.
INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS
See full prescribing information for complete boxed warnings.
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Page last updated 11/21/2023
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
