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- TRADE NAMES: Clozaril (Novartis); Denzapine (Merz); Entumin; Entumine; FazaClo; Klozapol; Leponex (Novartis); Lozapin; Sizopin; Zaponex (Teva)
- INDICATIONS: Treatment-resistant schizophrenia
- CLASS: Antipsychotic, Antipsychotic, atypical
- HALF-LIFE: 4–12 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Amitriptyline, Antimuscarinics, Arsenic, Benzodiazepines, Cabazitaxel, Caffeine, Carbamazepine, Chloramphenicol, Cimetidine, Ciprofloxacin, Citalopram, Cocoa, Cyclophosphamide, Cytotoxics, Darifenacin, Dasatinib, Encainide, Epinephrine, Erythromycin, Everolimus, Flecainide, Fluoxetine, Flupentixol, Fluphenazine, Fluvoxamine, Gefitinib, Guarana, Haloperidol, Insulin Degludec, Insulin Detemir, Insulin Glargine, Insulin Glulisine, Lapatinib, Lithium, Lomustine, Lorazepam, MAO inhibitors, Nilotinib, Norfloxacin, Ofloxacin, Omeprazole, Oxaliplatin, Oxybutynin, Paroxetine Hydrochloride, Pazopanib, Pemetrexed, Penicillamine, Pipotiazine, Propafenone, Quinidine, Rifampin, Risperidone, Ritonavir, Saquinavir, Selenium, Sertraline, Sorafenib, Sulfonamides, Sunitinib, Telithromycin, Temozolomide, Temsirolimus, Tetrazepam, Tricyclic antidepressants, Trospium, Uracil/Tegafur, Valproic Acid, Venlafaxine, Viloxazine, Zuclopenthixol
- See adverse reactions attributed to class:
Contra-indicated in patients with myeloproliferative disorders, uncontrolled epilepsy, paralytic ileus, or a history of clozapine-induced agranulocytosis or severe granulocytopenia.
AGRANULOCYTOSIS / SEIZURES / MYOCARDITIS / OTHER ADVERSE CARDIOVASCULAR AND RESPIRATORY EFFECTS.
INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS
See full prescribing information for complete boxed warnings.
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Page last updated 04/15/2025
