Clozapine
- TRADE NAMES: Clozaril (Novartis); Denzapine (Merz); Entumin; Entumine; FazaClo; Klozapol; Leponex (Novartis); Lozapin; Sizopin; Zaponex (Teva)
- INDICATIONS: Treatment-resistant schizophrenia
- CLASS: Antipsychotic
- HALF-LIFE: 4–12 hours
Alcohol, Amitriptyline, Antimuscarinics, Arsenic, Benzodiazepines, Cabazitaxel, Caffeine, Carbamazepine, Chloramphenicol, Cimetidine, Ciprofloxacin, Citalopram, Cocoa, Cyclophosphamide, Cytotoxics, Darifenacin, Dasatinib, Encainide, Epinephrine, Erythromycin, Everolimus, Flecainide, Fluoxetine, Flupentixol, Fluphenazine, Fluvoxamine, Gefitinib, Guarana, Haloperidol, Insulin Degludec, Insulin Detemir, Insulin Glargine, Insulin Glulisine, Lapatinib, Lithium, Lomustine, Lorazepam, MAO inhibitors, Nilotinib, Norfloxacin, Ofloxacin, Omeprazole, Oxaliplatin, Oxybutynin, Paroxetine Hydrochloride, Pazopanib, Pemetrexed, Penicillamine, Pipotiazine, Propafenone, Quinidine, Rifampin, Risperidone, Ritonavir, Saquinavir, Selenium, Sertraline, Sorafenib, Sulfonamides, Sunitinib, Telithromycin, Temozolomide, Temsirolimus, Tetrazepam, Tricyclic antidepressants, Trospium, Uracil/Tegafur, Valproic Acid, Venlafaxine, Viloxazine, Zuclopenthixol
PREGNANCY CATEGORY: B
Contra-indicated in patients with myeloproliferative disorders, uncontrolled epilepsy, paralytic ileus, or a history of clozapine-induced agranulocytosis or severe granulocytopenia.
AGRANULOCYTOSIS / SEIZURES / MYOCARDITIS / OTHER ADVERSE CARDIOVASCULAR AND RESPIRATORY EFFECTS
INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS
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Page last updated 03/02/2023
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
