Clozapine

BreastfeedingGeriatricPediatric
  • TRADE NAMES: Clozaril (Novartis); Denzapine (Merz); Entumin; Entumine; FazaClo; Klozapol; Leponex (Novartis); Lozapin; Sizopin; Zaponex (Teva)
  • INDICATIONS: Treatment-resistant schizophrenia
  • CLASS: Antipsychotic
  • HALF-LIFE: 4–12 hours

Contra-indicated in patients with myeloproliferative disorders, uncontrolled epilepsy, paralytic ileus, or a history of clozapine-induced agranulocytosis or severe granulocytopenia.

AGRANULOCYTOSIS / SEIZURES / MYOCARDITIS / OTHER ADVERSE CARDIOVASCULAR AND RESPIRATORY EFFECTS

INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS


See full prescribing information for complete boxed warnings.

Our database has 158 adverse reactions for this drug across the following areas

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SKIN.
HAIR.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
RENAL.
RESPIRATORY.
OTHER.


Page last updated 03/02/2023

Drug Eruption Mobile Site

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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