Ofloxacin
- TRADE NAMES: Bactocin; Exocine; Flobasin; Floxan; Floxil; Floxin (Ortho-McNeil); Floxstat; Ocuflox (Allergan); Oflocet; Oflocin; Tabrin; Taravid (Sanofi-Aventis)
- INDICATIONS: Various infections caused by susceptible organisms
- CLASS: Antibiotic, Antibiotic; fluoroquinolone, Antibiotic; quinolone, Antimicrobial
- HALF-LIFE: 4–8 hours
Aminophylline, Amiodarone, Antacids, Arsenic, Artemether/Lumefantrine, BCG Vaccine, Bendamustine, Bepridil, Bretylium, Calcium salts, Clozapine, Corticosteroids, Cyclosporine, CYP1A2 substrates, Didanosine, Disopyramide, Erythromycin, Insulin, Lanthanum, Magnesiuim salts, Mycophenolate, NSAIDs, Oral iron, Oral typhoid vaccine, Oxtriphylline, Phenothiazines, Probenecid, Procainamide, Quinapril, Quinidine, Sevelamer, Sotalol, St John's Wort, Strontium Ranelate, Sucralfate, Sulfonylureas, Tricyclic antidepressants, Vitamin K antagonists, Warfarin, Zinc, Zolmitriptan
PREGNANCY CATEGORY: C
Fluoroquinolones are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants.
Fluoroquinolones may exacerbate muscle weakness in persons with myasthenia gravis.
Ofloxacin is a racemate. See Levofloxacin for the adverse reactions of the (S)-isomer.
See full prescribing information for complete boxed warning.
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Page last updated 08/03/2022
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
