Valproic Acid
- TRADE NAMES: Depacon (AbbVie); Depakene (AbbVie); Depakote (AbbVie)
- INDICATIONS: Seizures, migraine
- SYNONYM: valproate sodium; divalproex
- CLASS: Anticonvulsant, Antipsychotic
- HALF-LIFE: 6–16 hours
Amitriptyline, Aspirin, Ceftobiprole, Cholestyramine, Clobazam, Clozapine, Doripenem, Eslicarbazepine, Ethosuximide, Imipenem/Cilastatin/Relebactam, Indinavir, Ivermectin, Lesinurad, Levomepromazine, Lumateperone, Meropenem, Meropenem & Vaborbactam, Olanzapine, Oxcarbazepine, Paliperidone, Risperidone, Rufinamide, Temozolomide, Tipranavir, Topiramate, Topiramate, Vorinostat, Zidovudine, Zinc, Zuclopenthixol
PREGNANCY CATEGORY: D
Gestational exposure to valproate is associated with an unacceptably high risk of major congenital malformations, neurodevelopmental disorders, and other adverse outcomes. Prescription of valproate to reproductive-age women is therefore strongly discouraged in many parts of the world.
See full prescribing information for complete boxed warning.
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Page last updated 08/29/2023
Symbol key
Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
