Valproic Acid

  • TRADE NAMES: Depacon (AbbVie); Depakene (AbbVie); Depakote (AbbVie)
  • INDICATIONS: Seizures, migraine
  • SYNONYM: valproate sodium; divalproex
  • CLASS: Anticonvulsant, Antipsychotic
  • HALF-LIFE: 6–16 hours

Gestational exposure to valproate is associated with an unacceptably high risk of major congenital malformations, neurodevelopmental disorders, and other adverse outcomes. Prescription of valproate to reproductive-age women is therefore strongly discouraged in many parts of the world.

LIFE-THREATENING ADVERSE REACTIONS

See full prescribing information for complete boxed warning.

Our database has 158 adverse reactions for this drug across the following areas

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SKIN.
HAIR.
NAILS.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
LOCAL.
NEUROMUSCULAR/SKELETAL.
OCULAR.
OTIC.
RENAL.
RESPIRATORY.
OTHER.


Page last updated 08/29/2023

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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