Paliperidone

BreastfeedingGeriatricPediatric
  • TRADE NAME: Invega (Janssen)
  • INDICATIONS: Schizophrenia
  • CLASS: Antipsychotic
  • HALF-LIFE: ~23 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

ACE inhibitors, Alcohol, Alpha blockers, Amphetamines, Angiotensin II receptor antagonists, Carbamazepine, CNS depressants, Dopamine agonists, Droperidol, General anesthetics, Itraconazole, Levodopa, Levomepromazine, Lithium, Methylphenidate, Metoclopramide, Myleosuppressives, P-glycoprotein inhibitors or inducers, Quinagolide, Risperidone, Tetrabenazine, Valproic Acid

PREGNANCY CATEGORY: C

Invega is not recommended for patients with creatinine clearance below 10 mL/min.

Paliperidone is the active metabolite of risperidone (see separate entry).

INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS

See full prescribing information for complete boxed warning.

Our database has 113 adverse reactions for this drug across the following areas

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SKIN.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
LOCAL.
NEUROMUSCULAR/SKELETAL.
OCULAR.
RENAL.
RESPIRATORY.
OTHER.


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Click on the DRUG REVIEW ARTICLE tab (above) to see a review of paliperidone in the Taylor & Francis journal Expert Opinion on Drug Safety. (Note that non-subscribers to the journal will only be able to see an abstract of the article.)

Page last updated 05/21/2020

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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