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- TRADE NAME: Crixivan (Merck)
- INDICATIONS: HIV infection
- CLASS: Antiretroviral, CYP3A4 inhibitor, HIV-1 protease inhibitor
- HALF-LIFE: ~1.8 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Abiraterone, Alfuzosin, Almotriptan, Alosetron, Alprazolam, Amiodarone, Amprenavir, Antacids, Antiarrhythmics, Antifungal agents, Artemether/Lumefantrine, Astemizole, Atazanavir, Atorvastatin, Atovaquone, Atovaquone/Proguanil, Avanafil, Bepridil, Bortezomib, Bosentan, Brigatinib, Brinzolamide, Cabazitaxel, Cabozantinib, Calcifediol, Calcium channel blockers, Carbamazepine, Chlordiazepoxide, Ciclesonide, Cisapride, Clarithromycin, Clonazepam, Clorazepate, Colchicine, Conivaptan, Copanlisib, Corticosteroids, Crizotinib, Cyclosporine, CYP3A4 inducers and substrates, Darifenacin, Darunavir, Dasatinib, Deferasirox, Delavirdine, Diazepam, Didanosine, Dienogest, Digoxin, Dihydroergotamine, Dronedarone, Dutasteride, Efavirenz, Enfuvirtide, Eplerenone, Ergot derivatives, Ergotamine, Estazolam, Estrogens, Etravirine, Everolimus, Felodipine, Fentanyl, Fesoterodine, Flibanserin, Flurazepam, Fluticasone Propionate, Food, Fusidic Acid, Grapefruit Juice, Guanfacine, H2-antagonists, Halazepam, Halofantrine, HMG-CoA reductase inhibitors, Itraconazole, Ixabepilone, Ketoconazole, Lapatinib, Lidocaine, Lomitapide, Lopinavir, Lovastatin, Maraviroc, Meperidine, Methylergonovine, Methylprednisolone, Methysergide, Midazolam, Midostaurin, Mifepristone, Mometasone, Nefazodone, Nelfinavir, Neratinib, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Nisoldipine, Olaparib, P-glycoprotein inhibitors and inducers, Paclitaxel, Palbociclib, Pantoprazole, Paricalcitol, Pazopanib, PEG-Interferon, Phenobarbital, Phenytoin, Pimavanserin, Pimecrolimus, Pimozide, Ponatinib, Prasugrel, Protease inhibitors, Proton pump inhibitors, Quazepam, Quinidine, Quinine, Ranolazine, Ribociclib, Rifabutin, Rifampin, Rifapentine, Rilpivirine, Rivaroxaban, Romidepsin, Rosuvastatin, Ruxolitinib, Salmeterol, Saxagliptin, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Solifenacin, Sorafenib, St John's Wort, Sunitinib, Tacrolimus, Tadalafil, Tamsulosin, Telithromycin, Temsirolimus, Tenofovir Disoproxil, Theophylline, Ticagrelor, Tolvaptan, Trazodone, Triazolam, Tricyclic antidepressants, Valproic Acid, Vardenafil, Vemurafenib, Venetoclax, Venlafaxine, Vorapaxar, Zidovudine
- See adverse reactions attributed to class:
Protease inhibitors cause dyslipidemia which includes elevated triglycerides and cholesterol and redistribution of body fat centrally to produce the so-called 'protease paunch', breast enlargement, facial atrophy, and 'buffalo hump'.
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Page last updated 07/31/2023
