Simvastatin
- TRADE NAMES: Denan; Inegy (MSD); Lipex; Liponorm; Lodales; Simcor (AbbVie); Simovil; Sivastin; Vytorin (MSD); Zocor (Merck); Zocord
- INDICATIONS: Hypercholesterolemia
- CLASS: HMG-CoA reductase inhibitor / statin
- HALF-LIFE: 1.9 hours
Alitretinoin, Amiodarone, Amlodipine, Amprenavir, Atazanavir, Azithromycin, Bempedoic acid, Boceprevir, Bosentan, Carbamazepine, Ciprofibrate, Clarithromycin, Clopidogrel, Colchicine, Conivaptan, Coumarins, Cyclosporine, Danazol, Darunavir, Dasatinib, Delavirdine, Diltiazem, Dronedarone, Efavirenz, Elbasvir & Grazoprevir, Erythromycin, Fosamprenavir, Fusidic Acid, Gemfibrozil, Glecaprevir & Pibrentasvir, Grapefruit Juice, HIV protease inhibitors, Imatinib, Imidazoles, Indinavir, Itraconazole, Ketoconazole, Letermovir, Lomitapide, Lonafarnib, Lopinavir, Miconazole, Mifepristone, Nefazodone, Nelfinavir, Ombitasvir/Paritaprevir/Ritonavir, Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir, Paclitaxel, Pazopanib, Posaconazole, Rabeprazole, Ranolazine, Red Rice Yeast, Rifampin, Ritonavir, Roxithromycin, Saquinavir, Selenium, St John's Wort, Tacrolimus, Telaprevir, Telithromycin, Ticagrelor, Tipranavir, Triazoles, Verapamil, Viloxazine, Voriconazole, Warfarin
PREGNANCY CATEGORY: X
Simcor is simvastatin and niacin; Vytorin is simvastatin and ezetimibe.
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Click on the DRUG REVIEW ARTICLE tab (above) to see a review of simvastatin and drug interactions in the Taylor & Francis journal Expert Opinion on Drug Safety. (Note that non-subscribers to the journal will only be able to see an abstract of the article.)
Page last updated 10/15/2022
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
