Bosentan drug interactions | Litt's Drug Eruption and Reaction Database

Bosentan

TRADE NAME: Tracleer (Actelion)
INDICATIONS: Pulmonary arterial hypertension
CLASS: Antihypertensive, Endothelin receptor (ETR) antagonist, Vasodilator
HALF-LIFE: ~5 hours

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Amiodarone, Amprenavir, Astemizole, Atazanavir, Atorvastatin, Boceprevir, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Alafenamide, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Cyclosporine, Diltiazem, Elbasvir & Grazoprevir, Enzalutamide, Erythromycin, Fluconazole, Fluvastatin, Glibenclamide, Glyburide, Ibrexafungerp, Indinavir, Itraconazole, Ketoconazole, Lemborexant, Levonorgestrel, Lopinavir, Lovastatin, Neratinib, Olaparib, Oral Contraceptives, Palbociclib, Progestogens, Reboxetine, Rifampin, Ritonavir, Sildenafil, Simvastatin, St John's Wort, Tacrolimus, Tadalafil, Telaprevir, Tipranavir, Ulipristal, Vardenafil, Venetoclax, Voriconazole, Warfarin

PREGNANCY CATEGORY: X

BLACK BOX WARNING

RISKS OF HEPATOTOXICITY and TERATOGENICITY

See full prescribing information for complete boxed warning.

Our database has 35 adverse reactions for this drug across the following areas

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SKIN.

CARDIOVASCULAR.

CENTRAL NERVOUS SYSTEM.

ENDOCRINE/METABOLIC.

GASTROINTESTINAL/HEPATIC.

GENITOURINARY.

HEMATOLOGIC.

NEUROMUSCULAR/SKELETAL.

RESPIRATORY.

OTHER.

Page last updated 01/19/2023

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Incidence

<1%
1-5%
5-10%
10-15%
15-20%
20-30%
>30%

Seriousness

Hospitalization possible
Life threatening
Fatal

Warnings in other populations

Breast feeding
Geriatric
Pediatric

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