Must be used in combination with PEG-interferon alfa and ribavirin (see separate entries)
- TRADE NAME: Incivek (Vertex)
- INDICATIONS: Hepatitis C (must only be used in combination with PEG-interferon alfa and ribavirin)
- CLASS: CYP3A4 inhibitor, Direct-acting antiviral, Hepatitis C virus NS3/4A protease inhibitor
- HALF-LIFE: 4–11 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alfuzosin, Alprazolam, Amiodarone, Amlodipine, Atazanavir, Atorvastatin, Bepridil, Bosentan, Budesonide, Carbamazepine, Cisapride, Dabigatran, Darunavir, Desipramine, Dexamethasone, Digoxin, Dihydroergotamine, Diltiazem, Efavirenz, Ergotamine, Escitalopram, Estradiol, Felodipine, Flecainide, Flibanserin, Fluticasone Propionate, Fosamprenavir, Itraconazole, Ketoconazole, Lidocaine, Lomitapide, Lovastatin, Methylergonovine, Methylprednisolone, Midazolam, Mifepristone, Nicardipine, Nisoldipine, Olaparib, Palbociclib, Phenobarbital, Phenytoin, Pimozide, Ponatinib, Posaconazole, Propafenone, Quinidine, Rifampin, Ritonavir, Ruxolitinib, Salmeterol, Sildenafil, Simvastatin, Sirolimus, St John's Wort, Tacrolimus, Tadalafil, Telithromycin, Tenofovir Disoproxil, Trazodone, Triazolam, Vardenafil, Venetoclax, Verapamil, Vorapaxar, Voriconazole, Warfarin, Zolpidem
- See adverse reactions attributed to class:
SERIOUS SKIN REACTIONS
See full prescribing information for complete boxed warning.
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Page last updated 07/31/2023
