Lotrel is benazepril and amlodipine. Lotensin-HCT is benazepril and hydrochlorothiazide.

Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.

Contra-indicated in patients with a history of angioedema with or without previous ACE inhibitor treatment.

See full prescribing information for complete boxed warning.