A hypersensitivity reaction – termed the 'sulfone syndrome' or 'dapsone syndrome' – may infrequently develop during the first six weeks of treatment. This syndrome consists of exfoliative dermatitis, fever, malaise, nausea, anorexia, hepatitis, jaundice, lymphadenopathy and hemolytic anemia.
- TRADE NAMES: Aczone (Allergan); Avlosulfon; Dapson; Dapson-Fatol; Maloprim; Protogen; Sulfona
- INDICATIONS: Leprosy, dermatitis herpetiformis, acne
- CLASS: Antibiotic, Antimicrobial, Antimycobacterial (including antitubercular)
- HALF-LIFE: 10–50 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Atovaquone/Proguanil, Chloroquine, Didanosine, Furazolidone, Ganciclovir, Hydroxychloroquine, Methotrexate, Pyrimethamine, Rifabutin, Rifampin, Rifapentine, Sulfonamides, Trimethoprim, Ursodiol
- See adverse reactions attributed to class:
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Page last updated 10/07/2023
