Pyrimethamine
- TRADE NAMES: Daraprim (GSK); Erbaprelina; Fansidar (Roche); Malocide; Pirimecidan
- INDICATIONS: Malaria
- CLASS: Antimalarial, Antimicrobial, Antiprotozoal
- HALF-LIFE: 80–95 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Dapsone, Pemetrexed, Trimethoprim, Zidovudine
PREGNANCY CATEGORY: C
Fansidar is pyrimethamine and sulfadoxine.
Sulfadoxine is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.
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SKIN.
MUCOSAL.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OTHER.
Page last updated 07/31/2023
Symbol key
Incidence
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric