Heparin

Geriatric
  • TRADE NAMES: Calcilean; Calciparin; Caprin; Hep-Flush (Wyeth); Hep-Lock; Hepalean; Heparin-Leo; Heparine; Liquemin; Uniparin; Viaflex (Baxter)
  • INDICATIONS: Venous thrombosis, pulmonary embolism, intravascular coagulation, peripheral arterial embolism
  • CLASS: Anticoagulant, Heparinoid
  • HALF-LIFE: 2 hours

See adverse reactions attributed to class:

Anticoagulant

A higher incidence of bleeding has been reported in patients over 60 years of age, especially women.

Contra-indicated in patients with severe thrombocyopenia.

Anaphylactoid reactions / anaphylaxis 

(2005): Warkentin TE+, Chest 127(5), 1857

(2004): Berkun Y+, Clin Exp Allergy 2004 Dec;34(12), 1916

(1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 249 (passim)

(1990): Bircher AJ+, Br J Dermatol 123, 507 (passim)

Angioedema <1%

(package insert)

Baboon syndrome (SDRIFE) 

(1993): Herfs H+, Hautarzt (German) 44, 466

Bullous dermatitis 

(2018): Snow SC+, Clin Exp Dermatol 43(4), 393-398

(2016): Gargallo V+, An Bras Dermatol 91(6), 857 (5 cases)

(2013): Choudhry S+, Cutis 91(2), 93 [REVIEW]

(2012): Maldonado Cid P+, J Am Acad Dermatol 67(5), e220 (5 cases)

(2009): Thuillier D+, Ann Dermatol Venereol 136(10), 705

Burning 

(soles)

(1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 249 (passim)

Dermatitis 

(2013): Choudhry S+, Cutis 91(2), 93 [REVIEW]

(1996): Boehncke WH+, Contact Dermatitis 35, 73

(1996): Koch P+, Contact Dermatitis 34(2), 156

(1995): Krasovec M+, Contact Dermatitis 32, 135

(1992): Valsecchi R+, Contact Dermatitis 26, 129

(1988): Young E, Contact Dermatitis 19, 152

Ecchymoses 

(2013): Choudhry S+, Cutis 91(2), 93 [REVIEW]

(1985): Tuneu A+, J Am Acad Dermatol 12, 1072

(1979): Stavorovsky M+, Dermatologica 158, 451

Eosinophilic fasciitis 

(1998): Cantini F+, J Rheumatol 25(2), 383 (3 cases)

Erythema 

(2013): Choudhry S+, Cutis 91(2), 93 [REVIEW]

(2005): Warkentin TE+, Chest 127(5), 1857 (4 cases)

Exanthems 

(1996): Warkentin TE, Br J Haematol 92, 494

(1994): Greiner D+, Hautarzt (German) 45, 569

Fixed eruption 

(1995): Mohammed KN, Dermatology 190, 91

Hematoma 

(2013): Choudhry S+, Cutis 91(2), 93 [REVIEW]

Hypersensitivity 

(2012): Leone S+, J Clin Pharm Ther 37(6), 733

(2005): Gaigl Z+, Br J Haematol 128(3), 389 (28 cases)

(2004): Liew G+, ANZ J Surg 74(11), 1020

(2002): Mora A+, Contact Dermatitis 47(3), 177

(2002): Nicolie B+, Allerg Immunol (Paris) 34(2), 47 [REVIEW]

(2000): Koch P+, J Am Acad Dermatol 42, 612

(1995): Sanders MN+, Int J Dermatol 34, 443

(1994): Patriarca G+, Allergy 49, 292

(1993): Dupin N+, Ann Dermatol Venereol (French) 120, 845

(1993): O'Donnell BF+, Br J Dermatol 129(5), 634

(1992): de Kort WJ+, Ned Tijdschr Geneeskd (Dutch) 136, 2379

(1992): Manoharan A, Eur J Haematol 48, 234

(1991): Rivers JK+, Aust N Z J Surg 61, 865 (24 cases)

(1989): Korstanje MJ+, Contact Dermatitis 20, 383

(1989): Patrizi A+, Contact Dermatitis 20, 309

(1973): Curry N+, Arch Intern Med 132, 744

Lesions 

(2012): Schindewolf M+, Lancet 380(9856), 1867

(2010): Schindewolf M+, J Thromb Haemost 8(7), 1486

Livedo reticularis 

(2005): Gibbs MB+, J Am Acad Dermatol 52(6), 1009

(1993): Gross AS+, Int J Dermatol 32, 276

Necrosis 

(2013): Choudhry S+, Cutis 91(2), 93 [REVIEW]

(2005): Warkentin TE+, Chest 127(5), 1857 (4 cases)

(2004): Housholder-Hughes SD, Am J Nurs 104(10), 16

(2003): Takwale A+, Br J Dermatol 148(6), 1292

(2002): Denoel C+, Rev Med Liege 57(8), 502

(2001): Andolfatto S+, Ann Biol Clin (Paris) 59(5), 651 (2 cases)

(2001): Denton MD+, Am J Nephrol 21(4), 289

(1997): Carter RL, N Engl J Med 336, 589

(1997): Kumar PD, N Engl J Med 336, 588

(1997): Libow LF+, Cutis 59, 242

(1997): McCloskey RV, N Engl J Med 336, 588

(1997): Schechter FG, N Engl J Med 336, 589

(1996): Christiaens GC+, N Engl J Med 335, 715

(1996): Whitmore SE+, Arch Dermatol 132, 341

(1995): Balestra B, Schweiz Med Wochenschr (German) 125, 361

(1994): Griffin JP, Adverse Drug React Toxicol Rev 13, 157 [REVIEW]

(1994): Leblanc M+, Nephron 68, 133

(1994): Peluso AM+, Eur J Dermatol 4, 127

(1994): Yoon TY+, Ann Dermatol 6, 74

(1993): Humphries JE, Acta Haematol 90, 52

(1993): Warkentin TE+, Am J Med 95, 662

(1993): Yates P+, Clin Exp Dermatol 18, 138

(1992): Calzavara-Pinton PG+, EJD 2, 171

(1992): Soundararajan R+, Am J Med 93, 467

(1992): Thomas D+, Chest 102, 1578

(1991): Humphries JE+, Am J Kidney Dis 17, 233

(1991): Ritchie AJ+, Ulster Med J 60, 248

(1990): Adcock DM+, Semin Thromb Hemost 16, 283 [REVIEW]

(1990): Bircher AJ+, Br J Dermatol 123, 507 (passim)

(1990): Fowlie J+, Postgrad Med J 66, 573 [REVIEW]

(1989): Armengol R+, Med Clin (Barc) (Spanish) 93, 699

(1989): Diem E, Hautarzt (German) 40, 239

(1989): Rongioletti F+, Dermatologica 178, 47

(1989): Vinti H+, Presse Med (French) 18, 128

(1988): Cohen GR+, Obstet Gynecol 73, 498

(1988): Hartman AR+, J Vasc Surg 7, 781 [REVIEW]

(1987): Alegre A+, Med Clin (Barc) (Spanish) 88, 170

(1987): Jones BF+, Australas J Dermatol 28, 117

(1986): Lim KB+, Singapore Med J 27, 356

(1985): Barthelemy H+, Ann Dermatol Venereol (French) 112, 245

(1985): Tuneu A+, J Am Acad Dermatol 12, 1072

(1984): Hasegawa GR, Drug Intell Clin Pharm 18, 313

(1984): Mathieu A+, Ann Dermatol Venereol (French) 111, 733

(1984): Monreal M+, Lancet 2, 820

(1984): Nodel'son SE+, Ter Arkh (Russian) 56(6), 118

(1984): Ulrick PJ+, Med J Aust 140, 287

(1983): Jehn U+, Dtsch Med Wochenschr (German) 108, 1148

(1983): Levine LE+, Arch Dermatol 119, 400

(1982): Isaacs P+, Br Med J Clin Res Ed 284, 201

(1982): No Author, Am J Hosp Pharm 39, 412

(1982): Shelley WB+, J Am Acad Dermatol 7, 674

(1981): Berkessy S+, Orv Hetil (Hungarian) 122, 3075

(1981): Jackson AM+, Br Med J Clin Res Ed 283, 1087

(1981): Kelly RA+, JAMA 246, 1582

(1980): Hall JC+, JAMA 244, 1831

(1979): White PW+, Ann Surg 190, 595

Nodular eruption 

(2013): Choudhry S+, Cutis 91(2), 93 [REVIEW]

Peripheral edema 

(1993): Phillips JK+, Br J Haematol 84, 349

Petechiae 

(2006): Perrinaud A+, J Am Acad Dermatol 54(2 Suppl), S5

(1979): Stavorovsky M+, Dermatologica 158, 451

Pruritus (itching) <1%

(package insert)

Purpura >10%

(package insert)

Rash 

(2012): Leone S+, J Clin Pharm Ther 37(6), 733 (facial)

Scleroderma 

(1985): Barthelemy H+, Ann Dermatol Venereol (French) 112, 245

Stevens-Johnson syndrome 

(2017): Bidaki R+, J Clin Diagn Res 11(5), Epub

Toxic dermatitis 

(1996): Gallais V+, Presse Med (French) 25, 1040

Toxic epidermal necrolysis 

(1991): Lemziakov TG+, Vrach Delo (Ukrainian) November, 113

(1985): Leung A, JAMA 253, 201

Ulcerations 

(2001): Denton MD+, Am J Nephrol 21(4), 289

Urticaria <1%

(2013): Choudhry S+, Cutis 91(2), 93 [REVIEW]

(1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 249 (passim)

(1990): Bircher AJ+, Br J Dermatol 123, 507 (passim)

(1975): Hancock BW+, BMJ 3, 746

(1964): Zinn WJ, Am J Cardiol 14, 36

(1962): Rajka G+, Acta Derm Venereol (Stockh) 42, 27

Vasculitis 

(2006): Patel N+, J R Soc Med 99(3), 151

(1989): Guillet G+, J Am Acad Dermatol 20, 1130

(1989): Korstanje MJ+, Contact Dermatitis 20(5), 383

(1982): Kearsley JH+, Aust N Z J Med 12, 288

(1979): Ranft K+, Med Welt (German) 30, 1489

(1979): Stavorovsky M+, Dermatologica 158, 451

Alopecia 

(1980): Jaques LB, Pharmacol Rev 31, 99

(1969): Levene GM, Br J Dermatol 81(3), 236

Gingivitis >10%

(package insert)

Thromboembolism 

(2012): Giossi A+, Blood Coagul Fibrinolysis 23(6), 559

Agitation 

(2017): Bidaki R+, J Clin Diagn Res 11(5), Epub

Delirium 

(2017): Bidaki R+, J Clin Diagn Res 11(5), Epub

Pain 

(2012): Leone S+, J Clin Pharm Ther 37(6), 733

Rectus sheath hematoma 

(2010): Barna L+, Orv Hetil 151 (28), 1145

Vomiting  

(2012): Leone S+, J Clin Pharm Ther 37(6), 733

Priapism 

(2004): Lin PH+, J Urol 172 (1)

(2001): Bauduer F+, Presse Med 30(8), 376

(2001): Bschleipfer TH+, Int J Impot Res 13(6), 357

(1999): De Siati M+, Arch Ital Urol Androl 71(3), 201

(1983): Burke BJ+, Postgrad Med J 59(691), 332

(1972): Klein LA+, J Urol 108(1), 104

Bleeding 

(2015): Diaz R+, J Pediatr 167(3), 64510%

(2014): Feldman A+, Int J Angiol 23(4), 2277%

Coagulopathy 

(2018): Sunseri M+, Case Rep Hematol Jan, Epub

Hemorrhage 

(2018): Sunseri M+, Case Rep Hematol Jan, Epub

(2016): Saleem N+, BMJ Case Rep Mar, Epub

(2011): Anevlavis S+, Respiration 81(6), 513

(2011): Rosenberger LH+, Crit Care Med 39(4), 833

(2010): van Elteren HA+, Neonatology 99(4), 247Pediatric

(1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 249 (passim)

(1986): Levine M+, Semin Thromb Hemost 12, 39

Thrombocytopenia 

(2020): Kumar R+, Br J Haematol Jan, Epub ahead of print [REVIEW]

(2020): Patriarcheas V+, Cureus 12(3), e7385 [REVIEW]

(2020): Riker RR+, Res Pract Thromb Haemost 4(5), 936-941 (3 cases)

(2019): Shmookler AD+, Transfus Apher Sci Jul, Epub ahead of print (1 case)

(2019): Voudris V+, Am J Case Rep 20, 753-757 (1 case / male)Geriatric

(2018): Cetinarslan O+, Turk Kardiyol Dern Ars 46(2), 136

(2018): Gallo T+, J Thromb Haemost Dec, Epub ahead of print

(2018): Karnes JH, Pharmacogenomics Nov, Epub ahead of print (passim)

(2018): Kimmoun A+, Intensive Care Med Aug, Epub ahead of print

(2018): Liu W+, Medicine (Baltimore) 97(50) (1 case)Geriatric

(2018): Pollak U+, Congenit Heart Dis 13(1), 16 [REVIEW]Pediatric

(2018): Prechel M+, Clin Appl Thromb Hemost Nov, Epub ahead of print (passim)

(2018): Prince M+, Postgrad Med J Aug, Epub ahead of print

(2018): Solanki J+, Semin Thorac Cardiovasc Surg Nov, Epub ahead of print

(2018): Topliceanu A+, BMJ Case Rep 2018 (1 case)Geriatric

(2018): Witten A+, J Mol Med (Berl) Jun, Epub ahead of print

(2017): Adediran S+, Case Rep Hematol Apr, Epub

(2017): Ito K+, Circ J 82(1), 293

(2017): Koster A+, Eur J Cardiothorac Surg 51(5), 1009

(2017): Kuter DJ+, Am J Hematol 92(8), 730

(2017): Pishko AM+, Semin Thromb Hemost 43(7), 691

(2017): Sin JH+, J Extra Corpor Technol 49(2), 115

(2017): Smith BW+, J Neurosurg Spine 26(5), 594

(2016): Bircan HA+, Eurasian J Med 48(1), 65

(2016): Devesa-Cordero C+, Int J Cardiol 223, 95 (fatal)Fatal

(2016): Fawaz B+, Proc (Bayl Univ Med Cent) 29(1), 60

(2016): Khoury M+, Thromb Res 146, 126 (2 cases) (intraoperative)

(2016): Ratzlaff RA+, BMJ Case Rep Dec, Epub

(2016): Salter BS+, J Am Coll Cardiol 67(21), 2519 [REVIEW]

(2016): Samos M+, J Cardiovasc Pharmacol 68(5), 391 [REVIEW]

(2016): Segna E+, Acta Otorhinolaryngol Ital 36(6), 527 [REVIEW]

(2016): Watanabe J+, Int J Angiol 25(5), e135

(2015): Al-Jafar H+, Case Rep Nephrol Dial 5(2), 152 (fatal)Fatal

(2015): Greinacher A, N Engl J Med 373(3), 252 [REVIEW]

(2015): Hoover J, N Engl J Med 373(19), 1882

(2015): Larsen PB+, Clin Case Rep 3(12), 987

(2015): Nazli Y+, Cardiovasc J Afr 26(3), e11 (fatal)Fatal

(2015): Warkentin TE+, N Engl J Med 372(5), 492

(2015): Yuan SM, Pak J Pharm Sci 28(5), 1793

(2015): Zhou J+, Zhong Nan Da Xue Xue Bao Yi Xue Ban (Chinese) 40(9), 1039 (fatal)FatalPediatric

(2014): Campisi S+, Ann Thorac Surg 98(6), e143

(2014): Mitomo H+, Kyobu Geka (Japanese) 67(13), 1139

(2014): Pericleous A+, Tex Heart Inst J 41(6), 645

(2014): Rao RV+, Circulation 129(11), e392

(2014): Sakakibara S+, Masui (Japanese) 63(3), 346

(2013): Prescrire Int 22(138), 124

(2013): Arnold DM+, Transfus Med Rev 27(3), 137

(2013): Benyounes N+, Presse Med 42(7-8), 1140

(2013): Craik JD+, Br J Haematol 161(2), 255

(2013): Dasararaju R+, Expert Rev Hematol 6(4), 419 [REVIEW]

(2013): Gur'ianov VA+, Anesteziol Reanimatol (Russian) (6), 60

(2012): Med Lett Drugs Ther 54(1391), 43

(2012): Chayanupatkul M+, BMJ Case Rep Dec, Epub [REVIEW]

(2012): Chow VW+, J Arthroplasty 27(7), 1413.e15

(2012): Cohen RA+, J Clin Med Res 4(1), 68 [REVIEW]

(2012): Cziraki A+, J Cardiothorac Surg 7(1), 23

(2012): Demma LJ+, J Thorac Cardiovasc Surg 143(5), 1213

(2012): Furuta Y+, Nihon Shokakibyo Gakkai Zasshi (Japanese) 109(6), 944

(2012): Gavranic BB+, Acta Med Croatica (Croatian) 66 Suppl 2, 68

(2012): Giossi A+, Blood Coagul Fibrinolysis 23(6), 559

(2012): Gumulec J, Vnitr Lek (Czech) 58(7-8), 564

(2012): Lanzarotti S+, Surg Clin North Am 92(6), 1559 [REVIEW]

(2012): McFarland J+, Am J Hematol 87(8), 776

(2012): Ozkan M+, J Heart Valve Dis 21(5), 6362%

(2012): Tanimura K+, J Obstet Gynaecol Res 38(4), 749 (in a pregnant woman)

(2012): Tomescot A+, Circulation 126(3), 378

(2012): Yamamoto N+, Gen Thorac Cardiovasc Surg 60(8), 511 (fatal)Fatal

(2011): Dalainas I+, J Cardiovasc Surg (Torino) 52(1), 81

(2011): Haeberle HA+, Anaesthesist 60(12), 1135

(2011): Richard S+, Platelets 22(2), 157 (1 case)

(2011): Rosenberger LH+, Crit Care Med 39(4), 833

(2010): Babuin L+, Vasc Health Risk Manag 6, 813

(2010): Butt A+, Compr Ther 36, 23

(2010): Chang IH+, J Korean Med Sci 25(9), 1390

(2010): Corbett TL+, J Thromb Thrombolysis 30(3), 375

(2010): Dolch ME+, Exp Clin Transplant 8(4), 329

(2010): Hajj-Chahine J+, Interact Cardiovasc Thorac Surg 11(5), 679

(2010): Hong MS+, Rev Cardiovasc Med 11(1), 13 [REVIEW]

(2010): Hook KM+, Curr Opin Hematol 17(5), 424

(2010): Ishihara-Kawase K+, Intern Med 49(10), 941

(2010): Joyner KA, Clin Lab Sci 23(3), 130 (1 case)

(2010): Kaiber FL+, An Bras Dermatol 85(6), 915

(2010): Kigawa I+, Kyobu Geka 63(6), 442 (1 case)

(2010): Majeed TA, Asian J Transfus Sci 4 (2)

(2010): Mathews EZ, J Hosp Med 5(3), E14 (fatal)Fatal

(2010): Montagnac R+, Nephrol Ther 6(7), 581

(2010): Nanda S+, Acta Cardiol 65(1), 93 (fatal)Fatal

(2010): Otis SA+, Am J Hematol 85(9), 700

(2010): Pendleton RC+, Clin Chest Med 31(4), 691

(2010): Prechel M+, Methods Mol Biol 663, 133

(2010): Rao NV+, Am J Physiol Cell Physiol 299(1), C97

(2010): Rissoul K+, Ann Biol Clin (Paris) 68(5), 555

(2010): Roncon-Albuquerque R Jr+, Clin Nephrol 73(4), 326

(2010): Rondina MT+, Hosp Pract (Minneap) 38(2), 19

(2010): Sachithanandan A, Interact Cardiovasc Thorac Surg 11(5), 681

(2010): Sandset PM, Curr Top Microbiol Immunol 341, 193

(2010): Saugel B+, Crit Care 14(3), R90

(2010): Schmidt KI+, Ann Thorac Surg 90(6), 2051 (1 case)

(2010): Thiele T+, Internist (Berl) 51(9), 1127

(2010): Warkentin TE, Hematol Oncol Clin North Am 24(4), 755

(2010): Wellborn-Kim JJ+, Am J Health Syst Pharm 67(13), 1075

(2010): Whitlatch NL+, Blood 116(10), 1761

(2010): Wong JK+, Anesth Analg 111(3), 609 (1 case)

(2009): Busche MN+, J Burn Care Res 30 (4), 747

(2009): Dave PA, East Afr Med J 86(12 Suppl), S62 [REVIEW]

(2009): Knobloch K+, Interact Cardiovasc Thorac Surg 8 (4) (life threatening)Fatal

(2009): Marques MB, Clin Lab Med 29(2), 321 [REVIEW] (life threatening)Fatal

(2008): Abdel-Wahab OI+, Acta Haematol 120(2), 117

(2008): Barginear MF+, Clin Appl Thromb Hemost 14(1), 105

(2008): Filis K+, Acta Haematol 120(3), 190

(2008): Howard-Thompson A+, Am J Health Syst Pharm 65(12), 1144

(2007): Warkentin TE, Hematol Oncol Clin North Am 21(4), 589 [REVIEW]

(2006): Warkentin TE, Hematology Am Soc Hematol Educ Program, 408 [REVIEW]

Thrombosis 

(2016): Segna E+, Acta Otorhinolaryngol Ital 36(6), 527 [REVIEW]

(2012): Hondo T+, Intern Med 51(6), 607Geriatric

(2011): Richard S+, Platelets 22(2), 157 (1 case)

(2010): Butt A+, Compr Ther 36, 23

(2010): Corbett TL+, J Thromb Thrombolysis 30(3), 375

(2010): Mathews EZ, J Hosp Med 5(3), E14 (fatal)Fatal

(2010): Sachithanandan A, Interact Cardiovasc Thorac Surg 11(5), 681

(2010): Schmidt KI+, Ann Thorac Surg 90(6), 2051 (1 case)

(2009): Dave PA, East Afr Med J 86(12 Suppl), S62 [REVIEW]

Injection-site eczematous eruption <1%

(2009): Thuillier D+, Ann Dermatol Venereol 136(10), 705

(2000): Koch P+, J Am Acad Dermatol 42, 612

(1995): Mathelier-Fusade P+, Presse Med (French) 24, 323

(1993): Phillips JK+, Br J Haematol 84, 349 (erythema)

(1990): Bircher AJ+, Br J Dermatol 123, 507

Injection-site induration 

(1993): Phillips JK+, Br J Haematol 84, 349

(1989): Guillet G+, J Am Acad Dermatol 20, 1130

(1989): Klein GF+, J Am Acad Dermatol 21, 703

(1987): Mayou SC+, Br J Dermatol 117, 664

Injection-site necrosis <1%

(1995): Mar AW+, Australas J Dermatol 36, 201 [REVIEW]

(1988): Cohen GR+, Obstet and Gyn 72, 498

(1984): Hasegawa GR, Drug Intell Clin Pharm 18, 313

(1980): Hall JC+, JAMA 244, 1831

Injection-site nodules 

(2002): Funt SA+, J Comput Assist Tomogr 26(4), 520

Injection-site pain 

(2001): Chan H, J Adv Nurs 35(6), 882

Injection-site plaques 

(2000): Koch P+, J Am Acad Dermatol 42, 612

(1990): Bircher AJ+, Br J Dermatol 123, 507

Injection-site purpura 

(2001): Chan H, J Adv Nurs 35(6), 882

Injection-site pyoderma 

(2014): Sobieszczanska M+, Hum Vaccin Immunother 10(4), 968

Osteoporosis 

(2010): Lefkou E+, Lupus 19(1), 3 [REVIEW]

Allergic reactions <10%

(2004): Tiu A+, N Z Med J 117(1204), U1126

(1997): Hermes B+, Acta Derm Venereol 77, 35

(1972): Lebeaupin R+, Anesth Analg (Paris) (French) 29, 487

Death 

(2016): Devesa-Cordero C+, Int J Cardiol 223, 95

(2015): Al-Jafar H+, Case Rep Nephrol Dial 5(2), 152 (1 case)

(2015): Nazli Y+, Cardiovasc J Afr 26(3), e11 (1 case)

(2015): Zhou J+, Zhong Nan Da Xue Xue Bao Yi Xue Ban (Chinese) 40(9), 1039 (1 case)Pediatric

(2010): Mathews EZ, J Hosp Med 5(3), e14

(2010): Nanda S+, Acta Cardiol 65(1), 93



Adverse reactions attributed to entire drug class Anticoagulant

Adverse effects 

(2017): Carrasco-Garrido P+, BMJ Open 7(1), Epub

(2017): Vu TT+, J Cutan Med Surg 21(6), 540 [REVIEW]

Page last updated 07/21/2020

Drug Eruption Mobile Site

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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