Primidone
- TRADE NAMES: Midone; Mylepsin; Mysoline (Xcel); PMS Primidone; Prysoline; Sertan
- INDICATIONS: Seizures
- CLASS: Anticonvulsant, Barbiturate
- HALF-LIFE: 10–12 hours
Alcohol, Amitriptyline, Amlodipine, Anticoagulants, Antihistamines, Betamethasone, Brompheniramine, Buclizine, Chlorpheniramine, Dexamethasone, Dichlorphenamide, Dicumarol, Doxycycline, Ethanolamine, Ethosuximide, Imatinib, Levomepromazine, Lopinavir, Metronidazole, Midazolam, Nelfinavir, Niacinamide, Paroxetine Hydrochloride, Perampanel, Pizotifen, Risperidone, Rufinamide, Telithromycin, Triamcinolone, Warfarin, Zafirlukast, Zuclopenthixol
PREGNANCY CATEGORY: D
Aromatic antiepileptic drugs, phenytoin, phenobarbital, carbamazepine and primidone, are a frequent cause of severe cutaneous adverse reactions. A strong genetic association between HLA-B*1502 and primidone-induced Stevens-Johnson syndrome and toxic epidermal necrolysis has been shown in Han Chinese patients.
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Page last updated 07/31/2023
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
