Aromatic antiepileptic drugs, phenytoin, phenobarbital, carbamazepine and primidone, are a frequent cause of severe cutaneous adverse reactions. A strong genetic association between HLA-B*1502 and primidone-induced Stevens-Johnson syndrome and toxic epidermal necrolysis has been shown in Han Chinese patients.
- TRADE NAMES: Midone; Mylepsin; Mysoline (Xcel); PMS Primidone; Prysoline; Sertan
- INDICATIONS: Seizures
- CLASS: Anticonvulsant (see also antiepileptic (anti-seizure)), Barbiturate
- HALF-LIFE: 10–12 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Amitriptyline, Amlodipine, Anticoagulants, Antihistamines, Betamethasone, Brompheniramine, Buclizine, Chlorpheniramine, Dexamethasone, Dichlorphenamide, Dicumarol, Doxycycline, Ethanolamine, Ethosuximide, Imatinib, Levomepromazine, Lopinavir, Metronidazole, Midazolam, Nelfinavir, Niacinamide, Paroxetine Hydrochloride, Perampanel, Pizotifen, Risperidone, Rufinamide, Telithromycin, Triamcinolone, Warfarin, Zafirlukast, Zuclopenthixol
- See adverse reactions attributed to class:
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Page last updated 11/07/2024
