Celecoxib is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.
NSAIDs may cause an increased risk of serious cardiovascular and gastrointestinal adverse events, which can be fatal. This risk may increase with duration of use.
Contra-indicated in patients with known hypersensitivity to celecoxib, aspirin, or other NSAIDs; in patients who have demonstrated allergic-type reactions to sulfonamides; in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; and for the treatment of peri-operative pain in the setting of coronary artery bypass graft surgery.
