Buprenorphine

BreastfeedingPediatric
  • TRADE NAMES: Probuphine (Braeburn); Suboxone (Reckitt Benckiser); Subutex (Reckitt Benckiser); Temgesic; Transtec (Napp)
  • INDICATIONS: Opioid dependence, moderate to severe pain
  • CLASS: Analgesic, Mixed opioid agonist/antagonist, Narcotic
  • HALF-LIFE: 37 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Antihistamines, Atazanavir, Azole antifungals, Benzodiazepines, Boceprevir, Carbamazepine, Cimetidine, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Alafenamide, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Delavirdine, Diazepam, Efavirenz, Erythromycin, HIV protease inhibitors, Hydrocodone, Hydromorphone, Ketoconazole, Ketorolac, Linezolid, Macrolide antibiotics, Morphine, Neuroleptics, Oxymorphone, Phenobarbital, Phenytoin, Rifampin, Ritonavir, Tapentadol, Tipranavir

PREGNANCY CATEGORY: C

Suboxone contains naloxone; Probuphine is an implant for subdermal administration.

ABUSE POTENTIAL, LIFE-THREATENING RESPIRATORY DEPRESSION, and ACCIDENTAL EXPOSURE

Probuphine: IMPLANT MIGRATION, PROTRUSION, EXPULSION, and NERVE DAMAGE ASSOCIATED WITH INSERTION and REMOVAL


See full prescribing information for complete boxed warning.

Our database has 83 adverse reactions for this drug across the following areas

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SKIN.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
LOCAL.
NEUROMUSCULAR/SKELETAL.
OCULAR.
OTIC.
RESPIRATORY.
OTHER.


Page last updated 04/26/2020

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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