Sodium Oxybate

BreastfeedingPediatric
  • TRADE NAME: Xyrem (Jazz)
  • INDICATIONS: Cataplexy (in patients with narcolepsy)
  • SYNONYM: GHB
  • CLASS: Anesthetic; general
  • HALF-LIFE: 0.3–1 hour
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Alcohol, Amitriptyline, Antipsychotics, Benzodiazepines, Clobazam, Hydromorphone, Hypnotics, Levomepromazine, Phenobarbital, Risperidone, Sedatives, Tricyclic depressants, Zuclopenthixol

PREGNANCY CATEGORY: B

NOTE

Sodium oxybate is a class of drugs that are also known as: designer drugs, party drugs, club drugs, recreational drugs, rave drugs, fantasy drugs, date rape drugs or abuse drugs.

BLACK BOX WARNING
Central nervous system depressant with abuse potential. Should not be used with alcohol or other CNS depressants.

See full prescribing information for complete boxed warning.

Our database has 136 adverse reactions for this drug across the following areas

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SKIN.
HAIR.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
OTIC.
RENAL.
RESPIRATORY.
OTHER.


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Click on the DRUG REVIEW ARTICLE tab (above) to see a review of sodium oxybate in the Taylor & Francis journal Expert Opinion on Drug Safety. (Note that non-subscribers to the journal will only be able to see an abstract of the article.)

Page last updated 07/31/2023

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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