Famotidine

Breastfeeding
  • TRADE NAMES: Apo-Famotidine; Duexis (Horizon); Durater; Famodil; Famoxal; Ganor; Gastro; Motiax; Mylanta AR; Nu-Famotidine; Pepcid (Valeant); Pepcidine; Pepdul; Sigafam
  • INDICATIONS: Duodenal ulcer, gastric ulcer, gastroesophageal reflux disease
  • CLASS: Histamine H2 receptor antagonist
  • HALF-LIFE: 2.5–3.5 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Acalabrutinib, Atazanavir, Cefditoren, Dasatinib, Delavirdine, Rilpivirine, Thalidomide

PREGNANCY CATEGORY: B

Under investigation for treating COVID-19

Duexis is famotidine and ibuprofen.

Anaphylactoid reactions / anaphylaxis 

(2010): Kim YI+, J Investig Allergol Clin Immunol 20 (2), 166

Angioedema <1%

(1986): Campoli-Richards DM+, Drugs 32, 197 [REVIEW]<1%

Candidiasis 

(2003): Orenstein SR+, Aliment Pharmacol Ther 17(9), 1097 (1 case)Pediatric

Dermatitis 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3974% (with ibuprofen)

(1994): Guimaraens D+, Contact Dermatitis 31, 259 [REVIEW]

(1990): Monteseirin J+, Contact Dermatitis 22, 290

Dermographism 

(1994): Warner DMc+, J Am Acad Dermatol 31, 677

Eczema 

(2015): Onda M+, BMJ Open 5(8), Epub

Erythema 

(2004): Horiuchi Y+, J Dermatol 31(7), 577

Erythema multiforme 

(1999): Horiuchi Y+, Ann Intern Med 131, 795

Excoriations 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3976% (with ibuprofen)

Flushing 

(1986): Campoli-Richards DM+, Drugs 32, 197 [REVIEW]<1%

Herpes zoster 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3974% (with ibuprofen)

Pemphigus 

(2008): Goldberg I+, Isr Med Assoc J 10(6), 424 [REVIEW]

Peripheral edema 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3975% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (with ibuprofen)

Pruritus (itching) <1%

(1994): Warner DMc+, J Am Acad Dermatol 31, 677

(1990): Edge DP, N Z Med J 103, 150

Purpura 

(1996): Kallal SM+, West J Med 164, 446 [REVIEW]

Rash 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3974% (with ibuprofen)

(1989): McCullough AJ+, Gastroenterology 97, 860

(1989): Schunack W, J Int Med Res 17 (Suppl 1), 9A

Urticaria <1%

(2002): Vasil'ev IuV+, Eksp Klin Gastroenterol (Russian) (4), 30 (3 cases)

(1994): Warner DMc+, J Am Acad Dermatol 31, 677

(1986): Campoli-Richards DM+, Drugs 32, 197 [REVIEW]<1%

Vasculitis (angiitis) / cutaneous vasculitis (angiitis) 

(1993): Torralba M+, An Med Interna (Spanish) 10, 621

(1990): Andreo JA+, Med Clin (Barc) (Spanish) 95, 234

Xerosis <1%

(package insert)

Nasal congestion 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3975% (with ibuprofen)

Oral lesions 

(1986): Campoli-Richards DM+, Drugs 32, 197 [REVIEW]<1%

Angina 

(2009): Taha AS+, Lancet 374(9684), 119 (2 cases) (with aspirin)

Cardiac arrest 

(1999): Schoenwald PK+, Anesthesiology 90(2), 623

Hypertension 

(2015): Bello AE+, Curr Med Res Opin 31(3), 407 (3 cases) (with ibuprofen)

(2015): Bello AE+, Curr Med Res Opin 31(3), 3979% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3273% (with ibuprofen)

Prolonged QT interval 

(2004): Lee KW+, Am J Cardiol 93(10), 1325 (2 cases)

Agitation 

(2003): Orenstein SR+, Aliment Pharmacol Ther 17(9), 1097 (2 cases)Pediatric

Anorexia 

(2003): Orenstein SR+, Aliment Pharmacol Ther 17(9), 1097 (2 cases)Pediatric

Aseptic meningitis 

(2000): Ishihara O+, Rinsho Shinkeigaku (Japanese) 40(1), 48

Confusion 

(2017): Chan GC+, Perit Dial Int 37(1), 118

(1998): Rodgers PT+, Pharmacotherapy 18 (2), 404Geriatric

Delirium 

(2017): Chan GC+, Perit Dial Int 37(1), 118

(2001): Yuan RY+, Ann Pharmacother 35(9), 1045Geriatric

(1996): Catalano G+, Psychosomatics 37(4), 349 (6 cases)

Depression 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3974% (with ibuprofen)

Disorientation 

(1998): Rodgers PT+, Pharmacotherapy 18 (2), 404Geriatric

Dysphasia 

(2013): Akahoshi T+, Fukuoka Igaku Zasshi 104(12), 483

Fever (pyrexia) 

(2006): Quan WD Jr+, Cancer Biother Radiopharm 21(6), 607 (with aldesleukin)

(2006): Quan WD Jr+, Cancer Biother Radiopharm 21(5), 437 (with aldesleukin)

Headache 5%

(2015): Bello AE+, Curr Med Res Opin 31(3), 3974% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3273% (with ibuprofen)

(2003): Orenstein SR+, Aliment Pharmacol Ther 17(9), 1097 (2 cases)

(2003): Orenstein SR+, Aliment Pharmacol Ther 17(9), 1097 (2 cases)Pediatric

Irritability 

(2003): Orenstein SR+, Aliment Pharmacol Ther 17(9), 1097 (2 cases)Pediatric

Mania 

(2002): von Einsiedel RW+, Pharmacopsychiatry 35(4), 152

Neurotoxicity 

(2012): Wu CS+, J Neurol 259(10), 2229

(1998): Odeh M+, J Clin Gastroenterol 27(3), 253 (5 cases)Geriatric

Nightmares 

(1998): Rodgers PT+, Pharmacotherapy 18 (2), 404Geriatric

Paresthesias <1%

(package insert)

Parkinsonism 

(2002): Katsumata S+, Nihon Naika Gakkai Zasshi (Japanese) 91(1), 456

Rigors 

(2006): Quan WD Jr+, Cancer Biother Radiopharm 21(6), 607 (with aldesleukin)

Seizures 

(2002): von Einsiedel RW+, Pharmacopsychiatry 35(4), 152

Somnolence (drowsiness) 

(2015): Onda M+, BMJ Open 5(8), Epub

(2003): Orenstein SR+, Aliment Pharmacol Ther 17(9), 1097 (3 cases)Pediatric

Vertigo / dizziness 1%

(package insert)

Galactorrhea 

(1995): Guven K+, Ann Pharmacother 29(7-8), 788

Hyperprolactinemia 

(1995): Guven K+, Ann Pharmacother 29(7-8), 788

Hypomagnesemia 

(2006): Quan WD Jr+, Cancer Biother Radiopharm 21(6), 607 (with aldesleukin)

(2006): Quan WD Jr+, Cancer Biother Radiopharm 21(5), 437 (with aldesleukin)

Hypophosphatemia 

(2006): Quan WD Jr+, Cancer Biother Radiopharm 21(6), 607 (with aldesleukin)

(2006): Quan WD Jr+, Cancer Biother Radiopharm 21(5), 437 (with aldesleukin)

Abdominal distension 

(2015): Bello AE+, Curr Med Res Opin 31(3), 39712% (with ibuprofen)

Abdominal pain 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3974% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3275% (with ibuprofen)

Constipation 1%

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3274% (with ibuprofen)

Diarrhea 2%

(2015): Bello AE+, Curr Med Res Opin 31(3), 3979% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3275% (with ibuprofen)

(2002): Vasil'ev IuV+, Eksp Klin Gastroenterol (Russian) (4), 30 (4 cases)

Dyspepsia 

(2015): Bello AE+, Curr Med Res Opin 31(3), 39712% (with ibuprofen)

(2013): Akahoshi T+, Fukuoka Igaku Zasshi 104(12), 483

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3275% (with ibuprofen)

Flatulence 

(2015): Bello AE+, Curr Med Res Opin 31(3), 39711% (with ibuprofen)

Gastroenteritis 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3978% (with ibuprofen)

Gastroesophageal reflux 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3975% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (exacerbation / with ibuprofen)

Hepatitis 

(2000): Jimenez-Saenz M+, Am J Gastroenterol 95(12), 3665Pediatric

Nausea 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3979% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3276% (with ibuprofen)

(2006): Quan WD Jr+, Cancer Biother Radiopharm 21(6), 607 (with aldesleukin)

(2006): Quan WD Jr+, Cancer Biother Radiopharm 21(5), 437 (with aldesleukin)

Vomiting  

(2015): Bello AE+, Curr Med Res Opin 31(3), 3974% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (with ibuprofen)

(2006): Quan WD Jr+, Cancer Biother Radiopharm 21(5), 437 (with aldesleukin)

(2003): Orenstein SR+, Aliment Pharmacol Ther 17(9), 1097 (1 case)Pediatric

Cystitis 

(2015): Poudel RR+, Clin Pharmacol 7, 83 (with tizanidine)

Urinary tract infection 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3979% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (with ibuprofen)

Anemia 

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (with ibuprofen)

Eosinophilia 

(2012): Wu CS+, J Neurol 259(10), 2229

(2004): Horiuchi Y+, J Dermatol 31(7), 577

Thrombocytopenia 

(2011): Compoginis JM+, Am Surg 77(12), 1580 (in trauma patients)

(2010): Brophy GM+, Neurocrit Care 13(2), 17617%

Arthralgia 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3976% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3271% (with ibuprofen)

Back pain 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3975% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (with ibuprofen)

Hallucinations, visual 

(1998): Rodgers PT+, Pharmacotherapy 18 (2), 404Geriatric

Retinopathy 

(2006): Lee YC+, Eye (Lond) 20(2), 260

Nephrotoxicity 

(1998): Hirayama K+, Nephrol Dial Transplant 13(10), 2636

Bronchitis 

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (with ibuprofen)

Cough 

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (with ibuprofen)

Influenza 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3975% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (with ibuprofen)

Nasopharyngitis 

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (with ibuprofen)

Pharyngolaryngeal pain 

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (with ibuprofen)

Sinusitis 

(2015): Bello AE+, Curr Med Res Opin 31(3), 39711% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3272% (with ibuprofen)

Upper respiratory tract infection 

(2015): Bello AE+, Curr Med Res Opin 31(3), 3978% (with ibuprofen)

(2012): Bello AE, Ther Adv Musculoskelet Dis 4(5), 3274% (with ibuprofen)

Adverse effects 

(2009): Taha AS+, Lancet 374(9684), 119 (9 cases) (with aspirin)

Allergic reactions <1%

(package insert)

Hiccups 

(2003): Orenstein SR+, Aliment Pharmacol Ther 17(9), 1097 (1 case)Pediatric

Side effects 

(1986): Campoli-Richards DM+, Drugs 32, 197 [REVIEW]<1%



Page last updated 10/07/2020

Drug Eruption Mobile Site

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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