Idelalisib

BreastfeedingPediatric
  • TRADE NAME: Zydelig (Gilead)
  • INDICATIONS: Relapsed chronic lymphocytic leukemia (with rituximab), follicular B-cell non-Hodgkin lymphoma, small lymphocytic lymphoma
  • CLASS: Phosphoinositide 3-kinase (PI3K) inhibitor
  • HALF-LIFE: 8 hours

FDA APPROVAL DATE: 07/23/2014

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Carbamazepine, Copanlisib, Midostaurin, Neratinib, Phenytoin, Rifampin, St John's Wort, Strong CYP3A inducers and substrates

PREGNANCY CATEGORY: D

FATAL AND SERIOUS TOXICITIES: HEPATIC, SEVERE DIARRHEA, COLITIS, PNEUMONITIS, and INTESTINAL PERFORATION

See full prescribing information for complete boxed warning.

Our database has 57 adverse reactions for this drug across the following areas

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SKIN.
MUCOSAL.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
LOCAL.
NEUROMUSCULAR/SKELETAL.
RESPIRATORY.
OTHER.


Page last updated 08/02/2021

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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