Litt’s Drug profile for Tafamidis meglumine

  • Trade Name: Vyndaqel (FoldRx Pharmaceuticals)
  • Indications: Cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis in adults. Transthyretin familial amyloid polyneuropathy (TTR-FAP).
  • Class: Transthyretin stabilizer
  • Half-life: 49 hours
  • FDA Approval Date: 05/03/2019
  • Clinically important, potentially hazardous interactions with:
    Breast Cancer Resistance Protein inhibitors, Imatinib, Methotrexate, Rosuvastatin
  • Pregnancy: Based on findings from animal studies, tafamidis may cause fetal harm when administered to a pregnant woman.

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Page last updated 08/20/2025

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Incidence - Help

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Seriousness - Help

Hospitalization possible
Life threatening
Fatal

Warnings in other populations - Help

BreastfeedingBreast feeding

GeriatricGeriatric

PediatricPediatric