Timolol

  • TRADE NAMES: Apo-Timol; Aquanil; Betimol; Blocadren (Merck); Cosopt (Merck); Dispatim; Nu-Timolol; Tenopt; Tiloptic; Timacor; Timolide (Merck); Timoptic (Merck); Timoptol
  • INDICATIONS: Hypertension
  • CLASS: Adrenergic beta-receptor antagonist
  • HALF-LIFE: 2–2.7 hours

Cosopt is timolol and dorzolamide; Timolide is timolol and hydrochlorothiazide. Dorzolamide and hydrochlorothiazide are sulfonamides and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.

Cutaneous side-effects of beta-receptor blockers are clinically polymorphous. They apparently appear after several months of continuous therapy.

Our database has 85 adverse reactions for this drug across the following areas

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SKIN.
HAIR.
NAILS.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
RESPIRATORY.
OTHER.


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Click on the DRUG REVIEW ARTICLE tab (above) to see a review of ophthalmic timolol in the Taylor & Francis journal Expert Opinion on Drug Safety. (Note that non-subscribers to the journal will only be able to see an abstract of the article.)

Page last updated 03/31/2022

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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