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INDICATIONS:Treatment of adults with unresectable or metastatic gastrointestinal stromal tumor harboring a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation, including PDGFRA D842V mutations.
Intracranial Hemorrhage: Withhold avapritinib for grade 1 or 2 reactions (subdural hematoma, intracranial hemorrhage, and cerebral hemorrhage) until resolution and then resume at a reduced dose. Permanently discontinue for recurrent grade 1 or 2 reactions or first occurrence of grade 3 or 4 reactions.
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