Contra-indicated in patients with undiagnosed abnormal genital bleeding, known or suspected estrogen-dependent neoplasia, active DVT or pulmonary embolism, or active arterial thromboembolic disease.
- TRADE NAME: Osphena (Shionogi)
- INDICATIONS: Dyspareunia due to menopausal vulvar and vaginal atrophy
- CLASS: Estrogen agonist, Estrogen antagonist, Selective estrogen receptor modulator (SERM)
- HALF-LIFE: 26 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Fluconazole, Ketoconazole, Other estrogen agonists or antagonists, Rifampin
- See adverse reactions attributed to class:
ENDOMETRIAL CANCER AND CARDIOVASCULAR DISORDERS
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Page last updated 07/31/2023
