St John's Wort

  • SCIENTIFIC NAMES: Hypericum perforatum; Kira (Lichtwer); Quanterra Emotional Balance (Warner Lambert)
  • INDICATIONS: Depression, dysthymic disorder, fatigue, insomnia, loss of appetite, anxiety, obsessive-compulsive disorders, mood disturbances, migraine headaches, neuralgia, fibrositis, sciatica, palpitations, exhaustion, headache, muscle pain, vitiligo, diuretic, bruises, abrasions, first-degree burns, hemorrhoids
  • SYNONYM: Hypericaceae
  • CLASS: Anxyolytic, CYP3A4 inducer
  • HALF-LIFE: 24–48 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Acetaminophen, Acitretin, Afatinib, Alfuzosin, Alitretinoin, Alprazolam, Ambrisentan, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Apixaban, Aprepitant, Artemether/Lumefantrine, Atazanavir, Atorvastatin, Bexarotene, Bictegravir/Emtricitabine/Tenofovir Alafenamide, Boceprevir, Bosentan, Brigatinib, Buspirone, Cabazitaxel, Cabozantinib, Carbamazepine, Ceritinib, Cilostazol, Ciprofloxacin, Citalopram, Cobimetinib, Conivaptan, Copanlisib, Crizotinib, Cyclosporine, Cyproterone, Dabigatran, Daclatasvir, Darunavir, Dasabuvir/Ombitasvir/Paritaprevir/Ritonavir, Dasatinib, Delavirdine, Demeclocycline, Digoxin, Doxycycline, Dronedarone, Duloxetine, Efavirenz, Eliglustat, Enzalutamide, Eplerenone, Escitalopram, Estradiol, Eszopiclone, Ethosuximide, Etoposide, Etravirine, Everolimus, Fenfluramine, Fesoterodine, Fexofenadine, Flibanserin, Fluoxetine, Fluvoxamine, Fosamprenavir, Gefitinib, Gemifloxacin, Ginkgo Biloba, Glecaprevir & Pibrentasvir, Hydromorphone, Ibrutinib, Idelalisib, Imatinib, Indinavir, Irinotecan, Isavuconazonium Sulfate, Isotretinoin, Ixabepilone, Ixazomib, Lacosamide, Lapatinib, Ledipasvir & Sofosbuvir, Levonorgestrel, Loperamide, Lopinavir, Lorcaserin, Lumacaftor/Ivacaftor, Maraviroc, Metaxalone, Methadone, Midazolam, Midostaurin, Mifepristone, Milnacipran, Naldemedine, Naratriptan, Nefazodone, Nelfinavir, Neratinib, Nevirapine, Nifedipine, Nilotinib, Nintedanib, Ofloxacin, Olaparib, Ombitasvir/Paritaprevir/Ritonavir, Omeprazole, Oral Contraceptives, Osimertinib, Oxcarbazepine, Palbociclib, Paroxetine Hydrochloride, Pazopanib, Perampanel, Phenobarbitone, Phenprocoumon, Phenytoin, Pimavanserin, Ponatinib, Quinolones, Raltegravir, Ramelteon, Regorafenib, Reserpine, Rilpivirine, Riociguat, Ritonavir, Rivaroxaban, Rizatriptan, Romidepsin, Safinamide, Saquinavir, Sertraline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sofosbuvir, Sofosbuvir & Velpatasvir, Sofosbuvir/Velpatasvir/Voxilaprevir, Solifenacin, Sonidegib, Sorafenib, SSRIs, Sumatriptan, Sunitinib, Tacrolimus, Tadalafil, Tapentadol, Telaprevir, Telithromycin, Temsirolimus, Tenofovir Alafenamide, Tetracyclines, Tezacaftor/Ivacaftor, Thalidomide, Tiagabine, Tipranavir, Tolvaptan, Trabectedin, Tricyclic antidepressants, Ulipristal, Valbenazine, Vandetanib, Venetoclax, Venlafaxine, Vigabatrin, Vorapaxar, Voriconazole, Warfarin, Ziprasidone, Zolmitriptan

PREGNANCY CATEGORY: N/A

St John's wort is a natural source of flavoring in Europe. Although not indigenous to Australia, and long considered a weed, St John's wort is now grown there as a cash crop and produces 20% of the world's supply.

Our database has 65 adverse reactions for this drug across the following areas

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SKIN
HAIR
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
NEUROMUSCULAR/SKELETAL
GASTROINTESTINAL/HEPATIC
RESPIRATORY
ENDOCRINE/METABOLIC
GENITOURINARY
HEMATOLOGIC
OTIC
OCULAR
OTHER


Page last updated 03/06/2018

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric