Darunavir

BreastfeedingPediatric
  • TRADE NAMES: Prezcobix (Janssen); Prezista (Janssen)
  • INDICATIONS: HIV infection (must be co-administered with ritonavir and with other antiretroviral agents)
  • CLASS: Antiretroviral, HIV-1 protease inhibitor
  • HALF-LIFE: 15 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Abacavir, Alfuzosin, Almotriptan, Alosetron, Alprazolam, Amiodarone, Antifungals, Apixaban, Artemether/Lumefantrine, Astemizole, Atorvastatin, Bortezomib, Brinzolamide, Calcium channel blockers, Captopril, Carbamazepine, Ciclesonide, Cisapride, Clarithromycin, Colchicine, Conivaptan, Cyclosporine, CYP2D6 substrates, CYP3A4 inhibitors, inducers and substrates, Dabigatran, Dasatinib, Deferasirox, Delavirdine, Didanosine, Dienogest, Digoxin, Dihydroergotamine, Dronedarone, Duloxetine, Dutasteride, Efavirenz, Elbasvir & Grazoprevir, Enfuvirtide, Eplerenone, Ergotamine, Estrogens, Etravirine, Everolimus, Fentanyl, Fesoterodine, Food, Fusidic Acid, Glecaprevir & Pibrentasvir, Guanfacine, Halofantrine, HMG-CoA reductase inhibitors, Indinavir, Inhaled corticosteroids, Ixabepilone, Ketoconazole, Lidocaine, Lopinavir, Lovastatin, Maraviroc, Meperidine, Methadone, Methylprednisolone, Midazolam, Mifepristone, Mometasone, Nefazodone, Nilotinib, Nisoldipine, Olaparib, P-glycoprotein substrates, Paricalcitol, Paroxetine Hydrochloride, Pazopanib, Phenobarbital, Phenytoin, Pimecrolimus, Pimozide, Prasugrel, Pravastatin, Protease inhibitors, Quetiapine, Quinidine, Quinine, Ranolazine, Rifabutin, Rifampin, Rilpivirine, Rivaroxaban, Romidepsin, Rosuvastatin, Salmeterol, Saquinavir, Saxagliptin, Sertraline, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Sorafenib, St John's Wort, Tacrolimus, Tadalafil, Tamsulosin, Telaprevir, Temsirolimus, Tenofovir Disoproxil, Terfenadine, Theophylline, Tolvaptan, Topotecan, Trazodone, Triazolam, Tricyclic antidepressants, Vardenafil, Voriconazole, Warfarin, Zidovudine

PREGNANCY CATEGORY: C

Darunavir is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.

Prezcobix is darunavir and cobicistat.

Our database has 35 adverse reactions for this drug across the following areas

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SKIN
CENTRAL NERVOUS SYSTEM
ENDOCRINE/METABOLIC
GASTROINTESTINAL/HEPATIC
NEUROMUSCULAR/SKELETAL
RENAL
OTHER


Page last updated 09/19/2018

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric