Irinotecan

BreastfeedingGeriatricPediatric
  • TRADE NAMES: Camptosar (Pfizer); Onivyde (Merrimack)
  • INDICATIONS: Metastatic colorectal carcinoma (Camptosar); metastatic adenocarcinoma of the pancreas (Onivyde - in combination with fluorouracil and leucovorin)
  • CLASS: Antineoplastic, Topoisomerase 1 inhibitor
  • HALF-LIFE: 6–10 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Aprepitant, Atazanavir, Bevacizumab, Ketoconazole, Lapatinib, Safinamide, Sorafenib, St John's Wort, Strong CYP3A4 inhibitors, Voriconazole

PREGNANCY CATEGORY: D

DIARRHEA and MYELOSUPPRESSION (Camptosar)

SEVERE NEUTROPENIA and SEVERE DIARRHEA (Onivyde)


See full prescribing information for complete boxed warnings.

Our database has 92 adverse reactions for this drug across the following areas

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SKIN
HAIR
NAILS
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
NEUROMUSCULAR/SKELETAL
GASTROINTESTINAL/HEPATIC
RESPIRATORY
ENDOCRINE/METABOLIC
GENITOURINARY
RENAL
HEMATOLOGIC
OCULAR
OTHER


Page last updated 11/13/2018

Drug Eruption Mobile Site

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric