Phenytoin

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Abacavir, Abiraterone, Acitretin, Afatinib, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, apatinib, Apixaban, Apremilast, Aprepitant, Artemether/Lumefantrine, Beclomethasone, Bictegravir/Emtricitabine/Tenofovir Alafenamide, Boceprevir, Brigatinib, Brivaracetam, Buprenorphine, Cabazitaxel, Cabozantinib, Caffeine, Calcium, Capecitabine, Caspofungin, Cefazolin, Ceritinib, Chloramphenicol, Cimetidine, Ciprofloxacin, Citalopram, Clobazam, Clorazepate, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Cobimetinib, Colesevelam, Copanlisib, Cyclosporine, Cyproterone, Dabigatran, Daclatasvir, Darunavir, Dasatinib, Deferasirox, Deflazacort, Delavirdine, Dexamethasone, Diazoxide, Disulfiram, Dopamine, Doxycycline, Dronedarone, Efavirenz, Elbasvir & Grazoprevir, Eliglustat, Emtricitabine/Rilpivirine/Tenofovir Alafenamide, Enasidenib, Enzalutamide, Erlotinib, Eslicarbazepine, Ethosuximide, Etravirine, Everolimus, Ezogabine, Fesoterodine, Flibanserin, Floxuridine, Fluconazole, Flunisolide, Fluoxetine, Fosamprenavir, Gefitinib, Gold & Gold Compounds, Hydrocortisone, Ibrutinib, Idelalisib, Imatinib, Indinavir, Influenza Vaccine, Isoniazid, Isotretinoin, Isradipine, Itraconazole, Ixabepilone, Ixazomib, Lacosamide, Ledipasvir & Sofosbuvir, Leflunomide, Letermovir, Levodopa, Levomepromazine, Levonorgestrel, Lisdexamfetamine, Lomustine, Lopinavir, Meperidine, Metformin, Methsuximide, Methylprednisolone, Metronidazole, Midazolam, Midostaurin, Mifepristone, Mivacurium, Naldemedine, Nelfinavir, Neratinib, Nifedipine, Nilotinib, Nilutamide, Nintedanib, Olaparib, Ombitasvir/Paritaprevir/Ritonavir, Ombitasvir/Paritaprevir/Ritonavir, Omeprazole, Ondansetron, Osimertinib, Oxcarbazepine, Oxtriphylline, Palbociclib, Paroxetine Hydrochloride, Pemetrexed, Perampanel, Phenylbutazone, Pimavanserin, Piracetam, Ponatinib, Posaconazole, Prednisolone, Prednisone, Propranolol, Regorafenib, Rifapentine, Rilpivirine, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Roflumilast, Romidepsin, Saquinavir, Simeprevir, Sofosbuvir, Sofosbuvir & Velpatasvir, Sofosbuvir/Velpatasvir/Voxilaprevir, Solifenacin, Sonidegib, Sorafenib, St John's Wort, Sucralfate, Sunitinib, Tegafur/Gimeracil/Oteracil, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Tenofovir Alafenamide, Tezacaftor/Ivacaftor, Thalidomide, Tiagabine, Ticagrelor, Ticlopidine, Tinidazole, Tipranavir, Tizanidine, Tolvaptan, Triamcinolone, Trimethoprim, Ulipristal, Uracil/Tegafur, Valbenazine, Vandetanib, Vemurafenib, Venetoclax, Vigabatrin, Vorapaxar, Voriconazole, Vortioxetine, Zidovudine, Zuclopenthixol

PREGNANCY CATEGORY: D

Aromatic antiepileptic drugs, phenytoin, phenobarbital, carbamazepine and primidone, are a frequent cause of severe cutaneous adverse reactions. A strong genetic association between HLA-B*1502 and phenytoin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis has been shown in Han Chinese patients.

Children whose mothers receive phenytoin during pregnancy are born with fetal hydantoin syndrome. The main features of this syndrome are mental and growth retardation, unusual facies, digital and nail hypoplasia, and coarse scalp hair. Occasionally neonatal acne will be present.

Our database has 144 adverse reactions for this drug across the following areas

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SKIN
HAIR
NAILS
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
ENDOCRINE/METABOLIC
GASTROINTESTINAL/HEPATIC
GENITOURINARY
HEMATOLOGIC
LOCAL
NEUROMUSCULAR/SKELETAL
OCULAR
RESPIRATORY
OTHER


Page last updated 01/30/2019

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric