Metformin

BreastfeedingGeriatricPediatric
  • TRADE NAMES: Apo-Metformin; Avandamet (GSK); Diabex; Diaformin; Diformin; Fortamet (Andrx); Gen-Metformin; Glucomet; Glucophage (Merck Serono); Glucovance (Merck Serono); Invokamet (Janssen); Janumet (Merck Sharpe & Dohme); Metaglip; Metforal; Metomin; Novo-Metformin; Riomet; Synjardy (Boehringer Ingelheim); Xigduo XR (AstraZeneca)
  • INDICATIONS: Diabetes
  • CLASS: Antidiabetic, Biguanide
  • HALF-LIFE: 6 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

ACE inhibitors, Acetazolamide, Alcohol, Amiloride, Anabolic steroids, Beta blockers, Bictegravir/Emtricitabine/Tenofovir Alafenamide, Calcium channel blockers, Captopril, Cephalexin, Cilazapril, Cimetidine, Corticosteroids, Diazoxide, Dichlorphenamide, Digoxin, Disopyramide, Diuretics, Enalapril, Estrogens, Fosinopril, Iodinated contrast agents, Isoniazid, Ketotifen, Lanreotide, Lisinopril, Luteinizing hormone releasing hormone analogs, MAO inhibitors, Morphine, Nicotinic acid, Octreotide, Oral Contraceptives, Pegvisomant, Phenothiazines, Phenytoin, Procainamide, Progestogens, Quinapril, Quinidine, Quinine, Ramipril, Ranitidine, Somatropin, Sympathomimetics, Testosterone, Thiazides, Thyroid products, Topiramate, Trandolapril, Triamterene, Trimethoprim, Trospium, Vancomycin, Zonisamide

PREGNANCY CATEGORY: B

Lactic acidosis is a rare, but serious, metabolic complication that can occur due to metformin accumulation.

Avandamet is metformin and rosiglitazone; Glucovance is metformin and glyburide; Invokamet is metformin and canagliflozin; Janumet is metformin and sitagliptin; Synjardy is metformin and empagliflozin; Xigduo XR is metformin and dapagliflozin.

LACTIC ACIDOSIS

See full prescribing information for complete boxed warning.

Our database has 94 adverse reactions for this drug across the following areas

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SKIN
HAIR
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
NEUROMUSCULAR/SKELETAL
GASTROINTESTINAL/HEPATIC
RESPIRATORY
ENDOCRINE/METABOLIC
GENITOURINARY
RENAL
HEMATOLOGIC
LOCAL
OTHER


Page last updated 03/13/2018

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric