Chlorpromazine
- TRADE NAMES: Chloractil; Chlorazin; Chlorpromanyl; Esmino; Largactil; Novo-Chlorpromazine; Ormazine; Propaphenin; Prozin; Thorazine (GSK)
- INDICATIONS: Psychosis, manic-depressive disorders
- CLASS: Antiemetic, Antipsychotic, Muscarinic antagonist, Phenothiazine
- HALF-LIFE: initial: 2 hours; terminal: 30 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Antihistamines, Arsenic, Asenapine, Chlorpheniramine, Dofetilide, Epinephrine, Evening Primrose, Guanethidine, Lisdexamfetamine, Mivacurium, Pimavanserin, Propranolol, Quinolones, Sodium Picosulfate, Sparfloxacin, Tetrabenazine, Zolpidem
PREGNANCY CATEGORY: N/A
The prolonged use of chlorpromazine can produce a gray-blue or purplish pigmentation over light-exposed areas. This is a result of either dermal deposits of melanin, a chlorpromazine metabolite, or a combination of both. Chlorpromazine melanosis is seen more often in women.
INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS
See full prescribing information for complete boxed warning.
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SKIN.
NAILS.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
OTIC.
RESPIRATORY.
OTHER.
Page last updated 08/29/2023
Symbol key
Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
