Dapsone

Breastfeeding
  • TRADE NAMES: Aczone (Allergan); Avlosulfon; Dapson; Dapson-Fatol; Maloprim; Protogen; Sulfona
  • INDICATIONS: Leprosy, dermatitis herpetiformis, acne
  • CLASS: Antibiotic, Antimycobacterial
  • HALF-LIFE: 10–50 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Atovaquone/Proguanil, Chloroquine, Didanosine, Furazolidone, Ganciclovir, Hydroxychloroquine, Methotrexate, Pyrimethamine, Rifabutin, Rifampin, Rifapentine, Sulfonamides, Trimethoprim, Ursodiol

PREGNANCY CATEGORY: C

A hypersensitivity reaction – termed the 'sulfone syndrome' or 'dapsone syndrome' – may infrequently develop during the first six weeks of treatment. This syndrome consists of exfoliative dermatitis, fever, malaise, nausea, anorexia, hepatitis, jaundice, lymphadenopathy and hemolytic anemia.

Our database has 91 adverse reactions for this drug across the following areas

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SKIN
NAILS
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
ENDOCRINE/METABOLIC
GASTROINTESTINAL/HEPATIC
HEMATOLOGIC
LOCAL
NEUROMUSCULAR/SKELETAL
OCULAR
RENAL
RESPIRATORY
OTHER


Page last updated 06/17/2019

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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