Litts Drug Eruption & Reaction Database - Presented by CRC Press

Nothing else can remotely compare to it.Patricia Wong, MD, Stanford University Medical Centre


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Drugs belonging to  restart save

class – Tyrosine kinase inhibitor – 34 items found

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Afatinib

Asciminib

Avapritinib

Axitinib

Bosutinib

Brigatinib

Cabozantinib

Crizotinib

Dacomitinib

Dasatinib

Erdafitinib

Erlotinib

Gefitinib

Imatinib

Lapatinib

Leflunomide

Lenvatinib

Mobocertinib

Neratinib

Nilotinib


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Adverse reactions attributed to entire drug class 'Tyrosine kinase inhibitor'

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Acute febrile neutrophilic dermatosis (Sweet's / Sweet syndrome)

    • (2021): Yang JJ+, Dermatol Ther 34(1), e14461 (14 cases) [REVIEW]

Cutaneous adverse reaction (includes severe cutaneous adverse drug reaction (SCAR))

    • (2022): Barbieri MA+, Front Oncol Nov (e-Collection) 58%
    • (2019): Clapes V+, Pharmaceut Med 33(1), 2123%

Cutaneous toxicity / skin toxicity

    • (2015): Macdonald JB+, J Am Acad Dermatol 72(2), 203 [REVIEW]

Edema / fluid retention

    • (2016): Yu L+, Zhonghua Xue Ye Xue Za Zhi (Chinese) 37(11), 92944%

Exanthems

    • (2018): Sanmartin O, Curr Probl Dermatol 53, 93

Hand–foot syndrome (palmar–plantar erythrodysesthesia)

    • (2023): Yeh CN+, Biol Trace Elem Res Mar, Online ahead of print [REVIEW]
    • (2018): Sanmartin O, Curr Probl Dermatol 53, 93

Ichthyosis

    • (2022): Park JS+, J Eur Acad Dermatol Venereol Sep, Online ahead of print [REVIEW] (association)

Pigmentation (Skin)

    • (2016): Yu L+, Zhonghua Xue Ye Xue Za Zhi (Chinese) 37(11), 92919%

Pyoderma gangrenosum

    • (2022): Khoshnam-Rad N+, Anticancer Drugs 33(1), e1-e8 (15 cases)

Rash

    • (2016): Yu L+, Zhonghua Xue Ye Xue Za Zhi (Chinese) 37(11), 92914%

Nail disorder

    • (2014): Prescrire Int 23(151), 180

Arrhythmias

    • (2021): Cheng M+, Front Cardiovasc Med Nov (e-Collection) [REVIEW]

Hypertension

    • (2020): Gadd M+, Cancer Rep (Hoboken) Aug, e1275
    • (2014): Fallahi P+, Expert Opin Drug Saf 13(6), 723 [REVIEW]

Thyroid dysfunction

    • (2024): Luna NA+, J ASEAN Fed Endocr Soc 39(2), 20-2640%
    • (2023): Leo S+, Ann Endocrinol (Paris) Mar, Online ahead of print [REVIEW]

Thyroiditis

    • (2017): Rizzo LFL+, Medicina (B Aires) 77(5), 394

Weight gain

    • (2016): Yu L+, Zhonghua Xue Ye Xue Za Zhi (Chinese) 37(11), 92912%

Gastrointestinal adverse reaction

    • (2023): Zhang P+, Therap Adv Gastroenterol Apr (e-Collection) [REVIEW]

Gastrointestinal disorder / discomfort

    • (2022): Barbieri MA+, Front Oncol Nov (e-Collection) 34%
    • (2019): Clapes V+, Pharmaceut Med 33(1), 2117%
    • (2016): Yu L+, Zhonghua Xue Ye Xue Za Zhi (Chinese) 37(11), 92932%

Hepatic (liver) disorder / hepatobiliary disorder / hepatic (liver) dysfunction

    • (2022): Barbieri MA+, Front Oncol Nov (e-Collection) 14%

Hepatotoxicity / liver injury / acute liver injury / drug-induced liver injury (DILI)

    • (2019): Carretero-Gonzalez A+, Medicine (Baltimore) 98(47), e18098 (3 cases) (previous treatment with immune checkpoint inhibitors also implicated)
    • (2016): Yu L+, Zhonghua Xue Ye Xue Za Zhi (Chinese) 37(11), 92912%
    • (2015): Karczmarek-Borowska B+, Contemp Oncol (Pozn) 19(2), 87 [REVIEW]

Cytopenia

    • (2016): Yu L+, Zhonghua Xue Ye Xue Za Zhi (Chinese) 37(11), 9298%

Asthenia / fatigue

    • (2016): Yu L+, Zhonghua Xue Ye Xue Za Zhi (Chinese) 37(11), 92938%
    • (2014): Fallahi P+, Expert Opin Drug Saf 13(6), 723 [REVIEW]

Muscle spasm

    • (2016): Yamada M+, Rinsho Ketsueki 57(4), 489
    • (2016): Yu L+, Zhonghua Xue Ye Xue Za Zhi (Chinese) 37(11), 92919%

Eyelashes – hypertrichosis (eyelash megalotrichosis)

    • (2024): Gershon R+, PLoS One 19(12), e0313326 [REVIEW]

Nephrotoxicity / kidney injury / acute kidney injury (AKI) / drug-induced kidney injury

    • (2023): Collotta D+, G Ital Nefrol (Italian) 40(Suppl 81), 2023-S81 [REVIEW]

Respiratory disorder

    • (2022): Barbieri MA+, Front Oncol Nov (e-Collection) 10%
    • (2019): Clapes V+, Pharmaceut Med 33(1), 2112%

Adverse effects / adverse reactions

    • (2025): Kyriacou NM+, Clin Transl Sci 18(5), e70224 [REVIEW]
    • (2023): Boskabadi SJ+, J Oncol Pharm Pract May, Online ahead of print [REVIEW]

Infection

    • (2022): Barbieri MA+, Front Oncol Nov (e-Collection) 16%

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