• TRADE NAMES: A-Acido; Aberal; Aberela; Acid A Vit; Acnavit; Acta; Airol; Aknemycin Plus (EM Industries); Alquingel; Alten; ATRA; Atragen; Avita; Avitcid; Avitoin; Cordes VAS; Derm A; Dermairol; Dermojuventus; Epi-Aberel; Eudyna; Relief; Renova (Ortho); Retin-A Micro (Ortho); Retinoic Acid; Retinova; Solage (Galderma); SteiVAA; Stieva-A; Vesanoid (Roche)
  • INDICATIONS: Acne vulgaris, skin aging, facial roughness, fine wrinkles, hyperpigmentation [T], acute promyelocytic leukemia [O]
  • SYNONYM: all-trans-retinoic acid; ATRA
  • CLASS: Antineoplastic / anticancer agent (see also Immune checkpoint inhibitor), Retinoid
  • HALF-LIFE: 0.5–2 hours
  • CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
    Aldesleukin, Bexarotene
  • PREGNANCY: category B (topical), category C (oral), category D in third trimester

Oral retinoids can cause birth defects, and women should avoid tretinoin when pregnant or trying to conceive. Avoid prolonged exposure to sunlight.

[T] = Topical; [O] = Oral.

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Page last updated 04/10/2024

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Incidence

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Seriousness

Hospitalization possible
Life threatening
Fatal

Warnings in other populations

BreastfeedingBreast feeding

GeriatricGeriatric

PediatricPediatric