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INDICATIONS:Palliative management of malignant neoplasms especially of the gastrointestinal tract, breast, liver and pancreas; topical therapy for actinic keratoses. Advanced pancreatic cancer (in combination with oxaliplatin/irinotecan/leucovorin (FOLFIRINOX or FOLFOXIRI)). Used in combination with leucovorin and irinotecan (FOLFIRI) for treatment of advanced-stage and metastatic colorectal cancer. Used in combination with leucovorin and oxaliplatin (FOLFOX; mFOLFOX6) for treatment of colorectal cancer.