Fluorouracil

BreastfeedingPediatric
  • TRADE NAMES: 5-fluorouracil (Taj); Carac (Valeant); Efudex (Valeant); Efudix; Efurix; Fluoroplex (Allergan); Fluorouracil Injection, USP (Bioniche); Tolak (Hill Dermac)
  • INDICATIONS:

    Palliative management of malignant neoplasms especially of the gastrointestinal tract, breast, liver and pancreas; topical therapy for actinic keratoses

    Advanced pancreatic cancer (in combination with oxaliplatin/irinotecan/leucovorin (FOLFIRINOX or FOLFOXIRI)) 

     Used in combination with leucovorin and irinotecan (FOLFIRI) for treatment of advanced-stage and metastatic colorectal cancer


  • CLASS: Antimetabolite, Antineoplastic
  • HALF-LIFE: 8–20 minutes
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Aldesleukin, Bromelain, Cimetidine, Granulocyte Colony-Stimulating Factor (G-CSF), Metronidazole, Tinidazole

PREGNANCY CATEGORY: X

NOTE

Contra-indicated in patients with dihydropyrimidine dehydrogenase deficiency.

Tolak cream contains peanut oil and should be used with caution in peanut-sensitive individuals.

Our database has 195 adverse reactions for this drug across the following areas

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SKIN.
HAIR.
NAILS.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
LOCAL.
NEUROMUSCULAR/SKELETAL.
OCULAR.
OTIC.
RENAL.
RESPIRATORY.
OTHER.


Page last updated 06/03/2020

Drug Eruption Mobile Site

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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