• TRADE NAMES: 5-fluorouracil (Taj); 5-FU; Carac (Valeant); Efudex (Valeant); Efudix; Efurix; Fluoroplex (Allergan); Fluorouracil Injection, USP (Bioniche); Tolak (Hill Dermac)
  • INDICATIONS: Palliative management of malignant neoplasms especially of the gastrointestinal tract, breast, liver and pancreas; topical therapy for actinic keratoses. Advanced pancreatic cancer (in combination with oxaliplatin/irinotecan/leucovorin (FOLFIRINOX or FOLFOXIRI)). Used in combination with leucovorin and irinotecan (FOLFIRI) for treatment of advanced-stage and metastatic colorectal cancer. Used in combination with leucovorin and oxaliplatin (FOLFOX; mFOLFOX6) for treatment of colorectal cancer.
  • CLASS: Antimetabolite, Antineoplastic / anticancer agent (see also Immune checkpoint inhibitor), Fluoropyrimidine
  • HALF-LIFE: 8–20 minutes

Contra-indicated in patients with dihydropyrimidine dehydrogenase deficiency.

Tolak cream contains peanut oil and should be used with caution in peanut-sensitive individuals.

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Page last updated 08/07/2024

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Incidence

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Seriousness

Hospitalization possible
Life threatening
Fatal

Warnings in other populations

BreastfeedingBreast feeding

GeriatricGeriatric

PediatricPediatric