Fluorouracil
- TRADE NAMES: 5-fluorouracil (Taj); 5-FU; Carac (Valeant); Efudex (Valeant); Efudix; Efurix; Fluoroplex (Allergan); Fluorouracil Injection, USP (Bioniche); Tolak (Hill Dermac)
- INDICATIONS: Palliative management of malignant neoplasms especially of the gastrointestinal tract, breast, liver and pancreas; topical therapy for actinic keratoses. Advanced pancreatic cancer (in combination with oxaliplatin/irinotecan/leucovorin (FOLFIRINOX or FOLFOXIRI)). Used in combination with leucovorin and irinotecan (FOLFIRI) for treatment of advanced-stage and metastatic colorectal cancer. Used in combination with leucovorin and oxaliplatin (FOLFOX; mFOLFOX6) for treatment of colorectal cancer.
- CLASS: Antimetabolite, Antineoplastic / anticancer agent
- HALF-LIFE: 8–20 minutes
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Aldesleukin, Bromelain, Cimetidine, Granulocyte Colony-Stimulating Factor (G-CSF), Metronidazole, Tinidazole
PREGNANCY CATEGORY: X
Contra-indicated in patients with dihydropyrimidine dehydrogenase deficiency.
Tolak cream contains peanut oil and should be used with caution in peanut-sensitive individuals.
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SKIN.
HAIR.
NAILS.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
LOCAL.
NEUROMUSCULAR/SKELETAL.
OCULAR.
OTIC.
RENAL.
RESPIRATORY.
OTHER.
Page last updated 09/15/2021
Symbol key
Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
