Amiloride

  • TRADE NAMES: Amikal; Kaluril; Medamor; Midamor (Merck); Midoride; Modamide; Moduretic (Merck); Nirulid; Ride
  • INDICATIONS: Prevention of hypokalemia associated with kaliuretic diuretics, management of edema in hypertension
  • CLASS: Diuretic, potassium-sparing
  • HALF-LIFE: 6–9 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

ACE inhibitors, Benazepril, Captopril, Cyclosporine, Enalapril, Fosinopril, Lisinopril, Magnesium, Metformin, Moexipril, Potassium salts, Quinapril, Quinidine, Ramipril, Spironolactone, Trandolapril, Zofenopril

PREGNANCY CATEGORY: B

Moduretic is amiloride and hydrochlorothiazide.

Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.

Our database has 25 adverse reactions for this drug across the following areas

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SKIN
HAIR
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
NEUROMUSCULAR/SKELETAL
RESPIRATORY
ENDOCRINE/METABOLIC
GENITOURINARY


Page last updated 04/18/2016

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric