Spironolactone

BreastfeedingPediatric
  • TRADE NAMES: Aldactazide (Pfizer); Aldactone (Pfizer); Aldopur; Almatol; Diram; Merabis; Novo-Spiroton; Osiren; Spiroctan; Tensin
  • INDICATIONS: Hyperaldosteronism, hirsutism, hypertension, edema for patients with congestive heart failure, cirrhosis of the liver or nephrotic syndrome
  • CLASS: Aldosterone antagonist, Diuretic
  • HALF-LIFE: 78–84 minutes
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

ACE inhibitors, Alcohol, Amiloride, Barbiturates, Benazepril, Captopril, Cyclosporine, Enalapril, Fosinopril, Lisinopril, Mitotane, Moexipril, Narcotics, NSAIDs, Potassium chloride, Potassium Iodide, Quinapril, Ramipril, Trandolapril, Triamterene, Zofenopril

PREGNANCY CATEGORY: C

Aldactazide is spironolactone and hydrochlorothiazide.

Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.

Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats

See full prescribing information for complete boxed warning.

Our database has 43 adverse reactions for this drug across the following areas

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SKIN
HAIR
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
ENDOCRINE/METABOLIC
GENITOURINARY
RENAL
HEMATOLOGIC
OTHER


Page last updated 04/26/2018

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric