Enalapril

Breastfeeding
  • TRADE NAMES: Amprace; Apo-Enalapril; Enaladil; Enapren; Glioten; Innovace (Merck Sharpe & Dohme); Lexxel (AstraZeneca); Pres; Renitec; Reniten; Teczem (Sanofi-Aventis); Vaseretic (Valeant); Vasotec (Valeant); Xanef
  • INDICATIONS: Hypertension, symptomatic congestive heart failure, asymptomatic left ventricular dysfunction
  • CLASS: Angiotensin-converting enzyme (ACE) inhibitor, Antihypertensive, Vasodilator
  • HALF-LIFE: 11 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Alcohol, Aldesleukin, Allopurinol, Alpha blockers, Alprostadil, Amifostine, Amiloride, Angiotensin II receptor antagonists, Antacids, Antidiabetics, Antihypertensives, Antipsychotics, Anxiolytics and hypnotics, Aprotinin, Azathioprine, Baclofen, Beta blockers, Calcium channel blockers, Clonidine, Conivaptan, Corticosteroids, Cyclosporine, CYP3A4 inducers, Deferasirox, Diazoxide, Diuretics, Eplerenone, Estrogens, Everolimus, General anesthetics, Gold & Gold Compounds, Grapefruit Juice, Heparins, Hydralazine, Hypotensives, Insulin, Levodopa, Lithium, MAO inhibitors, Metformin, Methyldopa, Methylphenidate, Minoxidil, Moxisylyte, Moxonidine, Nitrates, Nitroprusside, NSAIDs, Pentoxifylline, Phosphodiesterase 5 inhibitors, Potassium salts, Prostacyclin analogues, Quinine, Rituximab, Salicylates, Sirolimus, Spironolactone, Sulfonylureas, Tadalafil, Temsirolimus, Tizanidine, Tolvaptan, Triamterene, Trimethoprim

PREGNANCY CATEGORY: D
category C in first trimester; category D in second and third trimesters

Lexxel is enalapril and felodipine; Teczem is enalapril and diltiazem; Vaseretic is enalapril and hydrochlorothiazide.

Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.

Contra-indicated in patients with a history of angioedema with or without previous ACE inhibitor treatment.

FETAL TOXICITY

See full prescribing information for complete boxed warning.

Our database has 84 adverse reactions for this drug across the following areas

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SKIN
HAIR
NAILS
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
NEUROMUSCULAR/SKELETAL
GASTROINTESTINAL/HEPATIC
RESPIRATORY
ENDOCRINE/METABOLIC
GENITOURINARY
RENAL
OTHER


Page last updated 11/27/2017

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric