Hydrochlorothiazide
- TRADE NAMES: Accuretic (Pfizer); Aldactazide (Pfizer); Aldoril (Merck); Apo-Hydro; Atacand HCT (AstraZeneca); Avalide (Bristol-Myers Squibb); Capozide (Par); Clothia; Dichlotride; Diovan HCT (Novartis); Diu-Melsin; Diuchlor H; Dyazide (GSK); Esidrex; Hydrosaluric; Hyzaar (Merck); Inderide (Wyeth); Lopressor (Novartis); Lotensin (Novartis); Lotensin HCT (Novartis); Maxzide; Micardis (Boehringer Ingelheim); Microzide (Watson); Moduretic (Merck); Prinzide (Merck); Tekturna HCT (Novartis); Teveten HCT (Biovail); Uniretic (Schwarz); Urozide; Vaseretic (Biovail); Zestoretic (AstraZeneca); Ziac (Barr)
- INDICATIONS: Edema
- CLASS: Diuretic, thiazide
- HALF-LIFE: 5.6–14.8 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Digoxin, Dofetilide, Lithium, Zinc
PREGNANCY CATEGORY: B
Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.
Hydrochlorothiazide is often used in combination, e.g. with aliskiren (Tekturna HCT); amiloride (Moduretic); benazepril (Lotensin HCT); bisoprolol (Ziac); captopril (Capozide); enalapril (Vaseretic); irbesartan (Avalide); lisinopril (Prinzide and Zestoretic); losartan (Hyzaar); methyldopa (Aldoril); moexipril (Uniretic); spironolactone (Aldactazide); triamterene (Dyazide and Maxzide).
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SKIN.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
OTIC.
RENAL.
RESPIRATORY.
OTHER.
Page last updated 01/31/2024
Symbol key
Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
