Neostigmine
- TRADE NAME: Prostigmin (Valeant)
- INDICATIONS: Myasthenia gravis
- CLASS: Acetylcholinesterase inhibitor, Cholinesterase inhibitor, Parasympathomimetic
- HALF-LIFE: 52 minutes
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Aminoglycosides, Antiarrhythmics, Anticholinergics, Chloroquine, Clindamycin, Hydroxychloroquine, Kanamycin, Lithium, Local and general anesthetics, Neomycin, Non-depolarising muscle relaxants, Polymixins, Propafenone, Propranolol, Streptomycin, Succinylcholine
PREGNANCY CATEGORY: C
Anticholinesterase drugs may cause uterine irritability and induce premature labor when given intravenously to pregnant women near term
Neostigmine bromide is given orally; neostigmine methylsulfate is given parenterally.
Contra-indicated in patients with a previous history of reaction to bromides, or those with peritonitis or mechanical obstruction of the intestinal or urinary tract.
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SKIN.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
GASTROINTESTINAL/HEPATIC.
NEUROMUSCULAR/SKELETAL.
RESPIRATORY.
Page last updated 01/31/2024
Symbol key
Incidence
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric