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class – Proton pump inhibitor (PPI) – 6 items found

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Adverse reactions attributed to entire drug class 'Proton pump inhibitor (PPI)'

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Anaphylactoid reactions / anaphylaxis (includes anaphylactic shock)

(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

Angioedema (formerly named angioneurotic edema)

(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

Contact dermatitis

(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

Cutaneous adverse reaction (includes severe cutaneous adverse drug reaction (SCAR))

(2012): Chularojanamontri L+, J Drugs Dermatol 11(10), e43-7

DRESS syndrome (Drug-induced hypersensitivity syndrome / DIHS)

(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

Hypersensitivity

(2016): Otani IM+, Curr Allergy Asthma Rep 16(3), 17 [REVIEW]

Lichenoid eruption / lichenoid reaction

(2000): Bong JL+, BMJ 320(7230), 283

Lupus erythematosus (subacute cutaneous lupus erythematosus (SCLE))

(2017): Laurinaviciene R+, Eur J Dermatol 27(1), 28
(2016): Aggarwal N, Drugs Real World Outcomes 3(2), 145
(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN)

(2018): Forgerini M+, Sao Paulo Med J 136(6), 557 (severe) [REVIEW]
(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

Toxic epidermal necrolysis (Lyell's syndrome)

(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

Urticaria / hives

(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

Vasculitis / cutaneous vasculitis / small-vessel vasculitis

(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

(2019): Chrysant SG, Expert Rev Cardiovasc Ther May, Epub ahead of print [REVIEW] (passim)

Cardiac disorder / cardiac dysfunction

Cardiac disorder / cardiac dysfunction

(2018): Forgerini M+, Sao Paulo Med J 136(6), 557-570 [REVIEW]

Cardiac failure

(2018): Forgerini M+, Sao Paulo Med J 136(6), 557 [REVIEW]

(2025): Wang H+, Cardiovasc Toxicol May, Online ahead of print (with osimertinib) (with underlying comorbidities) (pharmacovigilance / pharmacoepidemiology)

Cardiovascular adverse effect (includes major adverse cardiovascular events (MACE))

Negative findings
(2023): Abukhalil AD+, Patient Prefer Adherence 17, 749-759 (with clopidogrel; no significant increase in cardiovascular events was observed in patients receiving concomitant clopidogrel and proton pump inhibitor therapy.)

Myocardial infarction

(2018): Forgerini M+, Sao Paulo Med J 136(6), 557 [REVIEW]

Myocardial infarction

Torsades de pointes

(2019): Chrysant SG, Expert Rev Cardiovasc Ther May, Epub ahead of print [REVIEW] (passim)

(2024): Decros A+, BMJ Open 14(10), e081911 (association) (pharmacovigilance / pharmacoepidemiology)

(2018): Forgerini M+, Sao Paulo Med J 136(6), 557 [REVIEW]

(2015): Cohen S+, Br J Clin Pharmacol 80(2), 200 [REVIEW]

Stroke / cerebrovascular accident

(2018): Forgerini M+, Sao Paulo Med J 136(6), 557 [REVIEW]

(2025): Jüchtern M, BMC Neurol 25(1), 380 (1 case / female) (with antihypertensive and statin therapy) (dose-related)
(2019): Chrysant SG, Expert Rev Cardiovasc Ther May, Epub ahead of print [REVIEW]
(2019): Chrysant SG+, Expert Opin Drug Saf Dec, Epub ahead of print [REVIEW]
(2016): William JH+, World J Nephrol 5(2), 152 [REVIEW]
(2014): Carter GT+, Phys Med Rehabil Clin N Am 25(2), 457
(2014): Park CH+, PLoS One 9(11), e112558 [REVIEW]
(2013): Wilhelm SM+, Expert Rev Clin Pharmacol 6(4), 443 [REVIEW]

Vitamin B-12 deficiency

(2022): Swarnakari KM+, Cureus 14(11), e31672 [REVIEW]

(2015): Cohen S+, Br J Clin Pharmacol 80(2), 200 [REVIEW]

(2015): Cohen S+, Br J Clin Pharmacol 80(2), 200 [REVIEW]

Gastric adenocarcinoma / gastric cancer

(2021): Salvo EM+, Aliment Pharmacol Ther Jun, Online ahead of print [REVIEW] (statistical association)

Gastrointestinal adverse reaction

(2021): Salvo EM+, Aliment Pharmacol Ther Jun, Online ahead of print [REVIEW] (statistical association)

Gut microbiome / gut microbiota / gastrointestinal microbiota changes / disturbance

(2024): Fossmark R+, Microorganisms 12(6), 1110 [REVIEW]

Hepatotoxicity / liver injury / acute liver injury / drug-induced liver injury (DILI)

(2024): Wang L+, Expert Opin Drug Saf Oct, Online ahead of print (23 cases) [REVIEW]

(2015): Cohen S+, Br J Clin Pharmacol 80(2), 200 [REVIEW]

Vomiting / emesis

(2025): Tezel Yalçın H+, Pharmaceuticals (Basel) 18(5), 7309% (pharmacovigilance / pharmacoepidemiology)

Cytopenia (see also pancytopenia)

(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

(2014): Shuman MD+, J Psychiatr Pract 20(1), 50 (with clozapine)

Pancytopenia (includes bicytopenia)

(2018): Yu Z+, Drug Saf Case Rep 5(1), 28 (1 case / male)

Thrombocytopenia / platelets decreased

(2025): Yue X+, Open Med (Wars) Oct (e-Collection) (18 cases) [REVIEW]
(2015): Binnetoglu E+, Platelets 26(1), 10
(2013): Wilhelm SM+, Expert Rev Clin Pharmacol 6(4), 443 [REVIEW]

(2018): Forgerini M+, Sao Paulo Med J 136(6), 557 [REVIEW]

(2021): Salvo EM+, Aliment Pharmacol Ther Jun, Online ahead of print [REVIEW] (statistical association)
(2016): Abramowitz J+, Otolaryngol Head Neck Surg 155(4), 547 [REVIEW]
(2013): Wilhelm SM+, Expert Rev Clin Pharmacol 6(4), 443 [REVIEW]

Myalgia/Myositis/Myopathy/Myotoxicity

(2017): Colmenares EW+, Ann Pharmacother 51(1), 66 [REVIEW]

(2013): Zofkova I, Vnitr Lek (Czech) 59(1), 59 [REVIEW]

(2013): Wilhelm SM+, Expert Rev Clin Pharmacol 6(4), 443 [REVIEW]

Nephrotoxicity / kidney injury / acute kidney injury (AKI) / drug-induced kidney injury

(2022): Wei X+, Drug Saf Jun, Online ahead of print [REVIEW]
(2021): Klatte DCF+, Ned Tijdschr Geneeskd (Dutch) 165, D5534 [REVIEW]
(2021): Salvo EM+, Aliment Pharmacol Ther Jun, Online ahead of print [REVIEW] (statistical association)
(2013): Wilhelm SM+, Expert Rev Clin Pharmacol 6(4), 443 [REVIEW]
(2012): Chang YS, Curr Opin Allergy Clin Immunol 12(4), 348 [REVIEW]

(2016): Abramowitz J+, Otolaryngol Head Neck Surg 155(4), 547 [REVIEW]

Adverse effects / adverse reactions

(2026): Corsello A+, Expert Rev Gastroenterol Hepatol Jun, Online ahead of print [REVIEW]
(2026): Wang C+, BMJ Evid Based Med Jun, Online ahead of print [REVIEW]
(2025): King E+, Cochrane Database Syst Rev 3, CD015127 [REVIEW]
(2025): Santi Laurini G+, Fundam Clin Pharmacol 39(4), e70036 [REVIEW] (pharmacovigilance / pharmacoepidemiology)
(2024): Alla D+, Glob Pediatr Health Apr (e-Collection) [REVIEW]
(2024): Bhatnagar MS+, Cureus 16(1), e52773 [REVIEW]
(2022): Chinzon D+, Arq Gastroenterol 59(2), 219-225 [REVIEW]
(2022): Dipasquale V+, Front Pharmacol Feb (e-Collection) [REVIEW]
(2022): Tyron JM+, Ugeskr Laeger (Danish) 184(15), V08210634 [REVIEW]
(2020): Savarino V+, Dig Liver Dis Jun, Online ahead of print [REVIEW]
(2017): Eusebi LH+, J Gastroenterol Hepatol 32(7), 1295 [REVIEW]
(2017): Schnoll-Sussman F+, Curr Treat Options Gastroenterol 15(1), 1 [REVIEW]
(2016): de la Coba Ortiz C+, Rev Esp Enferm Dig 108(4), 207 [REVIEW]

(2025): Hu S+, Medicine (Baltimore) 104(49), e46349 [REVIEW] (association) (pharmacovigilance / pharmacoepidemiology)
(2021): Salvo EM+, Aliment Pharmacol Ther Jun, Online ahead of print [REVIEW] (statistical association)
(2016): Abramowitz J+, Otolaryngol Head Neck Surg 155(4), 547 [REVIEW]

Preterm birth/labor

Preterm birth/labor

Preterm birth/labor

(2018): Forgerini M+, Sao Paulo Med J 136(6), 557-570 [REVIEW]

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