Litts Drug Eruption & Reaction Database - Presented by CRC Press

... an essential tool for dermatologists and other specialists Spencer D. Hawkins, The Dermatologist


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Drugs belonging to  restart save

class – Epidermal growth factor receptor (EGFR) inhibitor / antagonist – 12 items found

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Afatinib

Cetuximab

Dacomitinib

Erlotinib

Gefitinib

Lapatinib

Mobocertinib

Necitumumab

Neratinib

Osimertinib

Panitumumab

Vandetanib


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Adverse reactions attributed to entire drug class 'Epidermal growth factor receptor (EGFR) inhibitor / antagonist'

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Acneiform eruption / acneiform dermatitis / acneiform rash

    • (2023): Yuan C+, J Cosmet Dermatol Mar, Online ahead of print [REVIEW]
    • (2021): Zhang L+, BMJ Open 11(3), e046352 [REVIEW]
    • (2017): Tischer B+, Support Care Cancer 25(2), 651
    • (2016): Clabbers JM+, Support Care Cancer 24(2), 513
    • (2016): Lupu I+, J Med Life 9(1), 19 [REVIEW]
    • (2016): Sibaud V+, Clin Exp Dermatol 41(1), 34 (delayed)
    • (2015): Lupu I+, J Med Life 8(Spec Issue), 57
    • (2015): Melosky B+, Curr Oncol 22(2), 123
    • (2015): Nakahara T+, Onco Targets Ther 8, 259
    • (2012): Requena C+, Cutis 90(2), 77
    • (2012): Thaler J+, BMC Cancer 12, 438

Anaphylactoid reactions / anaphylaxis (includes anaphylactic shock)

    • (2016): Lupu I+, J Med Life 9(1), 19 [REVIEW]

Cutaneous toxicity / skin toxicity

    • (2024): Lee JS+, Acta Derm Venereol 104, adv40555
    • (2022): Lu CW+, J Eur Acad Dermatol Venereol Nov, Online ahead of print
    • (2017): Monjazeb S+, Skin Therapy Lett 22(5), 5
    • (2017): Stanculeanu DL+, Maedica (Buchar) 12(1), 48
    • (2015): Macdonald JB+, J Am Acad Dermatol 72(2), 203 [REVIEW]
    • (2014): Sinclair R, Asia Pac J Clin Oncol 10 Suppl 1, 11 [REVIEW]

Desquamation

    • (2012): Requena C+, Cutis 90(2), 77

Eczema / eczematous reaction / eczematous eruption

Erosive pustular dermatosis

    • (2023): Zhang Y+, Clin Exp Dermatol Sep, Online ahead of print (3 cases / female) (pharmacogenomics)

Erythema

    • (2015): Chanprapaph K+, Indian J Dermatol Venereol Leprol 81(5), 54711% [REVIEW]

Erythema dyschromicum perstans / ashy dermatosis

    • (2024): Bang AS+, Support Care Cancer 32(6), 354 (16 cases)

Fissures

Granulomas

    • (2022): Liu HL+, J Oncol Pharm Pract Sep, Online ahead of print (22 cases)

Hand–foot syndrome (palmar–plantar erythrodysesthesia)

    • (2017): Owczarek W+, Postepy Dermatol Alergol 34(5), 418 [REVIEW]
    • (2015): Lupu I+, J Med Life 8(Spec Issue), 57

Hypersensitivity

    • (2016): Berger MD+, Expert Opin Drug Saf 15(6), 799 [REVIEW]

Papulopustular eruption

    • (2024): Bălăceanu-Gurău B+, Cureus 16(11), e72878
    • (2019): Yalici-Armagan B+, Cutan Ocul Toxicol Apr, Epub ahead of print
    • (2018): Sanmartin O, Curr Probl Dermatol 53, 93
    • (2017): Owczarek W+, Postepy Dermatol Alergol 34(5), 418 [REVIEW]
    • (2016): Clabbers JM+, Support Care Cancer 24(2), 513
    • (2015): Chanprapaph K+, Indian J Dermatol Venereol Leprol 81(5), 54727% [REVIEW]
    • (2012): Hello M+, Rev Med Interne (French) 33(5), 273
    • (2011): Wu PA+, Curr Opin Oncol 23(4), 343 [REVIEW]

Photosensitivity

    • (2017): Lugovic-Mihic L+, Acta Clin Croat 56(2), 277 [REVIEW]

Pigmentation (Skin)

Pruritus (itching)

    • (2017): Owczarek W+, Postepy Dermatol Alergol 34(5), 418 [REVIEW]
    • (2016): Clabbers JM+, Support Care Cancer 24(2), 51317%
    • (2016): Lupu I+, J Med Life 9(1), 19 [REVIEW]
    • (2011): Wu PA+, Curr Opin Oncol 23(4), 343 [REVIEW]

Rash

    • (2024): Lai X+, Medicine (Baltimore) 103(23), e38277 [REVIEW] (association)
    • (2018): Aw DC+, Asia Pac J Clin Oncol 14(1), 23 [REVIEW]
    • (2017): Chan DLH+, Cochrane Database Syst Rev 6, CD007047 [REVIEW]
    • (2016): Berger MD+, Expert Opin Drug Saf 15(6), 799 [REVIEW]
    • (2016): Vogel WH+, J Adv Pract Oncol 7(7), 723 [REVIEW]
    • (2014): Hirsh V+, Curr Oncol 21(6), 329
    • (2014): Vaubel J+, J Eur Acad Dermatol Venereol 28(12), 1685

Rash

    • (2021): Shi X+, Front Oncol May (e-Collection) [REVIEW]

Telangiectases

Xerosis / xeroderma

    • (2018): Aw DC+, Asia Pac J Clin Oncol 14(1), 23 [REVIEW]
    • (2018): Sanmartin O, Curr Probl Dermatol 53, 93
    • (2017): Owczarek W+, Postepy Dermatol Alergol 34(5), 418 [REVIEW]
    • (2016): Clabbers JM+, Support Care Cancer 24(2), 51322%
    • (2016): Lupu I+, J Med Life 9(1), 19 [REVIEW]
    • (2015): Chanprapaph K+, Indian J Dermatol Venereol Leprol 81(5), 54753% [REVIEW]
    • (2012): Requena C+, Cutis 90(2), 77
    • (2012): Thaler J+, BMC Cancer 12, 438
    • (2011): Wu PA+, Curr Opin Oncol 23(4), 343 [REVIEW]

Alopecia / hair loss

    • (2017): Owczarek W+, Postepy Dermatol Alergol 34(5), 418 [REVIEW]

Curly hair

    • (2015): Herink C+, Hautarzt (German) 66(8), 617 (passim)

Hair changes

    • (2018): Sanmartin O, Curr Probl Dermatol 53, 93
    • (2016): Lupu I+, J Med Life 9(1), 19 [REVIEW]
    • (2011): Wu PA+, Curr Opin Oncol 23(4), 343 [REVIEW]

Nail changes

    • (2012): Garden BC+, J Am Acad Dermatol 67(3), 400 [REVIEW]
    • (2011): Wu PA+, Curr Opin Oncol 23 (4), 343

Nail disorder

    • (2014): Prescrire Int 23(151), 180
    • (2012): Requena C+, Cutis 90(2), 77

Paronychia

    • (2022): Liu HL+, J Oncol Pharm Pract Sep, Online ahead of print (22 cases)
    • (2018): Aw DC+, Asia Pac J Clin Oncol 14(1), 23 [REVIEW]
    • (2018): Sanmartin O, Curr Probl Dermatol 53, 93
    • (2017): Owczarek W+, Postepy Dermatol Alergol 34(5), 418 [REVIEW]
    • (2016): Lupu I+, J Med Life 9(1), 19 [REVIEW]
    • (2016): Vogel WH+, J Adv Pract Oncol 7(7), 723 [REVIEW]
    • (2015): Chanprapaph K+, Indian J Dermatol Venereol Leprol 81(5), 5475% [REVIEW]
    • (2015): Melosky B+, Curr Oncol 22(2), 123
    • (2012): Hello M+, Rev Med Interne (French) 33(5), 273
    • (2012): Thaler J+, BMC Cancer 12, 438

Pyogenic granuloma

Mucositis

    • (2024): An Z+, Laryngoscope Investig Otolaryngol 9(3), e1279 (grade 3–4) [REVIEW]
    • (2017): Vigarios E+, Support Care Cancer 25(5), 1713 [REVIEW]
    • (2016): Vogel WH+, J Adv Pract Oncol 7(7), 723 [REVIEW]
    • (2015): Chanprapaph K+, Indian J Dermatol Venereol Leprol 81(5), 5477% [REVIEW]

Nasal vestibulitis

    • (2015): Ruiz JN+, Support Care Cancer 23(8), 2391 [REVIEW]

Oral ulceration

    • (2024): An Z+, Laryngoscope Investig Otolaryngol 9(3), e1279 (grade 3–4) [REVIEW]

Stomatitis (oral mucositis)

    • (2018): Aw DC+, Asia Pac J Clin Oncol 14(1), 23 [REVIEW]
    • (2016): Vogel WH+, J Adv Pract Oncol 7(7), 723 [REVIEW]
    • (2015): Melosky B+, Curr Oncol 22(2), 123

Cardiotoxicity

    • (2024): Wang Y+, Front Oncol Jun (e-Collection) [REVIEW]

Hypomagnesemia

    • (2021): Zhang L+, BMJ Open 11(3), e046352 [REVIEW]
    • (2016): Berger MD+, Expert Opin Drug Saf 15(6), 799 [REVIEW]
    • (2016): Jiang DM+, Clin Colorectal Cancer 15(3), e117 [REVIEW]

Diarrhea

    • (2024): Lai X+, Medicine (Baltimore) 103(23), e38277 [REVIEW] (association)
    • (2023): Cárdenas-Fernández D+, Ther Adv Med Oncol Aug (e-Collection) [REVIEW]
    • (2021): Shi X+, Front Oncol May (e-Collection) [REVIEW]
    • (2021): Zhang L+, BMJ Open 11(3), e046352 [REVIEW]
    • (2018): Aw DC+, Asia Pac J Clin Oncol 14(1), 23 [REVIEW]
    • (2017): Chan DLH+, Cochrane Database Syst Rev 6, CD007047 [REVIEW]
    • (2016): Vogel WH+, J Adv Pract Oncol 7(7), 723 [REVIEW]
    • (2014): Hirsh V+, Curr Oncol 21(6), 329

Gastrointestinal adverse reaction

    • (2023): Zhang P+, Therap Adv Gastroenterol Apr (e-Collection) [REVIEW]

Vaginal bleeding

    • (2022): Yu M+, Front Oncol Jun (e-Collection) 69% (abnormal menstruation)

Myelosuppression / bone marrow suppression / myelotoxicity

    • (2021): Zhang L+, BMJ Open 11(3), e046352 [REVIEW]

Ocular adverse effect

    • (2016): Vogel WH+, J Adv Pract Oncol 7(7), 723 [REVIEW]

Trichomegaly

    • (2015): Chanprapaph K+, Indian J Dermatol Venereol Leprol 81(5), 5472% [REVIEW]
    • (2012): Thaler J+, BMC Cancer 12, 438

Nephrotoxicity / kidney injury / acute kidney injury (AKI) / drug-induced kidney injury

    • (2017): Izzedine H+, Nephrol Dial Transplant 32(7), 1089

Interstitial lung disease / interstitial pneumonitis / interstitial pneumonia (cryptogenic organizing pneumonia) / drug-induced interstitial lung disease

    • (2023): Kashizaki F+, Clin Lung Cancer Oct, Online ahead of print14% [REVIEW]

Nasopharyngeal necrosis

    • (2024): An Z+, Laryngoscope Investig Otolaryngol 9(3), e1279 (grade 3–4) (Reported as an adverse reaction event for patients with nasopharyngeal carcinoma following radiotherapy)

Pneumothorax

    • (2020): Guo R+, Thorac Cancer 11(7), 2031-2035 (3 cases) (with microwave ablation)

Pulmonary toxicity

    • (2016): Vogel WH+, J Adv Pract Oncol 7(7), 723 [REVIEW]
    • (2014): Johkoh T+, Clin Lung Cancer 15(6), 448

Adverse effects / adverse reactions

    • (2024): An Z+, Laryngoscope Investig Otolaryngol 9(3), e1279 (grade 3–4) [REVIEW]
    • (2023): Liao D+, Int Immunopharmacol Feb, Online ahead of print (with immune checkpoint inhibitor)
    • (2020): Huang J+, Sci Rep 10(1), 4803 [REVIEW]
    • (2020): Zhou JY+, Expert Opin Drug Saf Apr, Epub ahead of print [REVIEW]
    • (2019): Zhao Y+, BMJ 367, 15460 [REVIEW]
    • (2017): Below J+, Hautarzt (German) 68(1), 12 [REVIEW] (cutaneous)
    • (2015): Sharma A+, Perspect Clin Res 6(2), 1091%

Infection

    • (2024): Lai X+, Medicine (Baltimore) 103(23), e38277 [REVIEW] (association)

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