Litts Drug Eruption & Reaction Database - Presented by CRC Press

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Drugs belonging to  restart save

class – Statin (see HMG-CoA reductase inhibitor)

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Adverse reactions attributed to entire drug class 'Statin (see HMG-CoA reductase inhibitor)'

Please login to view adverse reactions.

Adverse reactions

Angioedema (formerly named angioneurotic edema)

Dermatomyositis

    • (2019): Visconti MJ+, Int J Dermatol Dec, Epub ahead of print [REVIEW]

Hypersensitivity

Lupus erythematosus (subacute cutaneous lupus erythematosus (SCLE))

    • (9999): Laurinaviciene R+, Eur J Dermatol Oct, Epub ahead of print

Pityriasis lichenoides / pityriasis lichenoides chronica / pityriasis lichenoides et varioliformis acuta

    • (2012): Massay RJ+, West Indian Med J 61(7), 743 (3 cases)

Pruritus (itching)

    • (2017): Kim H+, Basic Clin Pharmacol Toxicol 121(5), 4095%

Vesiculobullous eruption

Hypotension

Cognitive impairment

    • (2019): Tan B+, Expert Rev Clin Pharmacol Apr, Epub ahead of print [REVIEW]
    • (2017): Mulchandani R+, Acta Cardiol Nov, Epub ahead of print~20%

Confusion

Depression

Headache

Hypoesthesia (numbness)

    • (2017): Mulchandani R+, Acta Cardiol Nov, Epub ahead of print31%

Memory loss/memory impaired

Neuropathy

Neurotoxicity

    • (2014): Tuccori M+, CNS Drugs 28(3), 249

Paresthesias

    • (2017): Mulchandani R+, Acta Cardiol Nov, Epub ahead of print31%

Diabetes mellitus

    • (2016): Oscanoa Espinoza TJ+, Rev Fac Cien Med Univ Nac Cordoba (Spanish) 73(4), 263 [REVIEW]
    • (2015): Dobrzynski JM+, Curr Atheroscler Rep 17(2), 477

Dyspepsia / functional dyspepsia (indigestion) (see also gastroparesis)

    • (2017): Kim H+, Basic Clin Pharmacol Toxicol 121(5), 4096%

Hepatitis

    • (2020): Qasim Agha O+, BMJ Case Rep 13(2), e232391 (1 case)

Hepatotoxicity / liver injury / acute liver injury / drug-induced liver injury (DILI)

    • (2020): Meurer L+, Clin Liver Dis 24(1), 107 [REVIEW]
    • (2017): Naiqiong W+, Med Sci Monit 23, 5760
    • (2016): Wang LY+, Br J Clin Pharmacol 82(3), 823
    • (2015): Bjornsson ES, Arch Toxicol 89(3), 327
    • (2015): Dobrzynski JM+, Curr Atheroscler Rep 17(2), 477
    • (2014): Berta E+, Pharmazie 69(6), 42039%

Pancreatitis / acute pancreatitis

    • (2015): Kuoppala J+, Pharmacoepidemiol Drug Saf 24(10), 1085

Erectile dysfunction

Impotence

Eosinophilia / eosinophils increased

Asthenia / fatigue

    • (2017): Millan J+, Clin Investig Arterioscler (Spanish) 29(1), 743%

Bone pain / joint pain

    • (2017): Mulchandani R+, Acta Cardiol Nov, Epub ahead of print~20%

Muscle spasm

    • (2017): Millan J+, Clin Investig Arterioscler (Spanish) 29(1), 728%

Myalgia/Myositis/Myopathy/Myotoxicity

    • (2021): Alzueta N+, Eur J Hosp Pharm 28(2), 115-117 (1 case)
    • (2020): Kee PS+, Front Genet Oct (e-Collection) [REVIEW]
    • (2020): Madgula AS+, Cureus 12(4), e7500 (1 case)
    • (2020): Mirlesse N+, Age Ageing Mar, Epub ahead of print (1 case) (autoimmune myopathy)
    • (2020): Nikolic D+, Expert Opin Drug Saf Apr, Epub ahead of print [REVIEW]
    • (2020): Qasim Agha O+, BMJ Case Rep 13(2), e232391 (1 case)
    • (2019): Berent T+, Atheroscler Suppl Aug, Epub ahead of print
    • (2018): Kosinski C+, Rev Med Suisse (French) 14(596), 462 [REVIEW]
    • (2018): Wooten JM, South Med J 111(1), 39 [REVIEW]
    • (2017): Guemara R+, Rev Med Suisse (French) 13(562), 1013
    • (2017): Kim H+, Basic Clin Pharmacol Toxicol 121(5), 40912%
    • (2017): Millan J+, Clin Investig Arterioscler (Spanish) 29(1), 778%
    • (2017): Mulchandani R+, Acta Cardiol Nov, Epub ahead of print32–47%
    • (2017): Nazir S+, J Clin Rheumatol 23(3), 149 [REVIEW] (autoimmune myopathy)
    • (2016): Pedro-Botet J+, Expert Opin Drug Saf 15(12), 158378%
    • (2015): Dobrzynski JM+, Curr Atheroscler Rep 17(2), 477
    • (2014): Ahmad Z, Am J Cardiol 113(10), 1765
    • (2014): Berta E+, Pharmazie 69(6), 42055%
    • (2014): Brygger L+, Expert Opin Drug Saf Sep, Epub ahead of print
    • (2014): Ganga HV+, Am Heart J 168(1), 6 [REVIEW]
    • (2014): Jiang Y+, Zhonghua Xin Xue Guan Bing Za Zhi (Chinese) 42(11), 905
    • (2013): Mohassel P+, Muscle Nerve 48(4), 477 [REVIEW] (autoimmune myopathy)
    • (2011): Abd TT+, Expert Opin Drug Saf 10(3), 373 [REVIEW]

Rhabdomyolysis

    • (2021): Safitri N+, Drug Healthc Patient Saf 13, 211-219 [REVIEW]
    • (2018): Kosinski C+, Rev Med Suisse (French) 14(596), 462 [REVIEW]
    • (2017): Millan J+, Clin Investig Arterioscler (Spanish) 29(1), 73%
    • (2016): Ambapkar SN+, J Assoc Physicians India 64(7), 93
    • (2016): Oscanoa Espinoza TJ+, Rev Fac Cien Med Univ Nac Cordoba (Spanish) 73(4), 263 [REVIEW]
    • (2016): Pedro-Botet J+, Expert Opin Drug Saf 15(12), 15833%
    • (2015): Simons JE+, J Clin Lipidol 9(4), 594
    • (2014): Jiang Y+, Zhonghua Xin Xue Guan Bing Za Zhi (Chinese) 42(11), 905
    • (2012): Hoffman KB+, PLoS One 7(8), e42866

Statin-induced necrotizing autoimmune myopathy

    • (2022): Ganta N+, Cureus 14(2), e22273 (1 case / male)
    • (2021): Alzueta N+, Eur J Hosp Pharm 28(2), 115-117
    • (2021): Fidalgo C+, Acta Med Port Sep, Online ahead of print (2 cases)
    • (2020): Huda SA+, Proc (Bayl Univ Med Cent) 34(1), 185-186 (1 case / male)
    • (2020): Meyer A+, Arthritis Res Ther 22(1), 5 (55 cases)
    • (2013): Hamann PD+, Autoimmun Rev 12(12), 1177-81 [REVIEW]

Tendinopathy/Tendon rupture

    • (2016): Knobloch K, Adv Exp Med Biol 920, 229

Cataract

    • (2014): Wise SJ+, Can J Cardiol 30(12), 1613
    • (2013): Lei JY+, Zhonghua Yan Ke Za Zhi (Chinese) 49(5), 468 [REVIEW]

Diplopia (double vision)

Vision blurred

    • (2015): Mizranita V+, Int J Clin Pharm 37(5), 844

Vision impaired

    • (2015): Mizranita V+, Int J Clin Pharm 37(5), 844

Pneumonia

Pulmonary toxicity

    • (2014): Bonniaud P+, Rev Prat (French) 64(7), 951 [REVIEW]

Adverse effects / adverse reactions

    • (2021): Lin JL+, J Atheroscler Thromb Sep, Online ahead of print
    • (2021): Yee J+, J Pers Med 11(7), 677 [REVIEW]
    • (2020): Conte C+, Fundam Clin Pharmacol Feb, Epub ahead of print [REVIEW]Pediatric
    • (2020): Mulchandani R+, Expert Opin Drug Saf Jul, Online ahead of print [REVIEW]
    • (2020): Thomas JP+, Eur J Clin Pharmacol Jul, Online ahead of print [REVIEW]
    • (2019): Bae HJ+, Korean J Intern Med Aug, Epub ahead of print12%
    • (2018): Bellosta S+, Expert Opin Drug Saf 17(1), 25 [REVIEW] (from drug interactions)
    • (2017): Atonstad S, Tidsskr Nor Laegeforen (Norwegian) 137(1), 36
    • (2015): de Keyser CE+, Eur J Endocrinol 173(2), 155 (low testosterone levels in males)
    • (2014): Berta E+, Pharmazie 69(6), 42024% (gastrointestinal)
    • (2014): Desai CS+, BMJ 349, g3743 [REVIEW]

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