Immune Globulin IV

Breastfeeding
  • TRADE NAMES: Allerglobuline; Baygam; Beriglobulin; Citax; Endobulin; Gamafine; Gamastan; Gamimune (Bayer); Gamma 16; Gammabulin; Gammagard (Baxter); Gammar PIV (ZLB Behring); Gammer-IV; Gammonayiv; Gamunex (Bayer); IG Gamma; IGIM; Interglobin; IV Globulin-S; Iveegam (Baxter); Octagam; Panglobulin; Pentaglobin; Polygam S/D; Sandoglobulin; Sandoglobulina; Sandoglobuline; Venoglobulin (Alpha Therapeutics)
  • INDICATIONS: Immunodeficiency in patients unable to produce sufficient amounts of IgG antibodies
  • SYNONYM: IGIV; IVIG; Octagam
  • CLASS: Covid-19 putative drug, Immunomodulator
  • HALF-LIFE: N/A
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Live vaccines

PREGNANCY CATEGORY: C

Under investigation for treating COVID-19

See adverse reactions attributed to class:

Covid-19 putative drug

Immunomodulator

THROMBOSIS, RENAL DYSFUNCTION and ACUTE RENAL FAILURE

See full prescribing information for complete boxed warning.

Anaphylactoid reactions / anaphylaxis (includes anaphylactic shock) 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

(2017): Hoffmann JHO+, J Dtsch Dermatol Ges 15(12), 1211

(2015): Mehta A+, Indian J Dermatol 60(3), 230 [REVIEW]

(2013): Berger M, J Allergy Clin Immunol Pract 1(6), 558

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Dyshidrosis 

(2003): Uyttendaele H+, J Drugs Dermatol 2(3), 337

Eczema 

(2017): Yoon KL+, Korean Circ J 47(2), 209Pediatric

(2014): Miyamoto J+, JAMA Dermatol 150(10), 1120

(2012): Gerstenblith MR+, J Am Acad Dermatol 66(2), 31275%

Flushing / rubefaction 

(2014): Lederer DJ+, PLoS One 9(8), Epub9%

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Inflammation 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

Lichenoid eruption 

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

(1998): Smith KJ+, J Cutan Med Surg 3(2), 96

Lupus erythematosus 

(2017): Adrichem ME+, J Peripher Nerv Syst 22(3), 213

Petechiae 

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Pompholyx / dyshidrotic eczema 

(2014): Brazzelli V+, Int J Immunopathol Pharmacol 27(1), 127Pediatric

(2012): Gerstenblith MR+, J Am Acad Dermatol 66(2), 31263%

(1999): Iannaccone S+, Neurology 53(5), 1154

Pruritus (itching) 

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (palms / passim)

Rash 

(2012): Novak P+, BMC Neurol 12

(2003): Wittstock M+, Eur Neurol 50(3), 172

Serum sickness-like reaction 

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Stevens-Johnson syndrome 

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Urticaria / hives 

(2017): Han JW, Korean Circ J 47(2), 179

Vasculitis (angiitis) / cutaneous vasculitis (angiitis) 

(2012): Kollert F+, Clin Exp Rheumatol 30(6), 982

(2001): Odum J+, Nephrol Dial Transplant 16(2), 403

(1998): Howse M+, BMJ 317(7168), 1291

(1996): Hashkes PJ+, Clin Exp Rheumatol 14(6), 673

Alopecia / hair loss 

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Bradycardia / sinus bradycardia 

(2017): Raheja H+, Am J Ther Sep, Epub ahead of print

Cardiotoxicity 

(2016): Ammann EM+, Am J Hematol 91(6), 594 [REVIEW]

Chest pain 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

Hypertension 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

(2017): Han JW, Korean Circ J 47(2), 179

(2014): Quest GR+, Transfusion 54(12), 3088 (transfusion-related)

(2010): Mitzel-Kaoukhov H+, Ann Allergy Asthma Immunol 104 (3), 253

Hypotension 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

Myocardial infarction 

(2017): Agrawal Y+, Am J Ther 24(6), e689

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Palpitation 

(2014): Dash CH+, PLoS One 9(6), Epub3%

(2014): Lederer DJ+, PLoS One 9(8), Epub9%

Tachycardia 

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Thromboembolism 

(2017): Hoffmann JHO+, J Dtsch Dermatol Ges 15(12), 1211

(2014): Ramirez E+, Thromb Res 133(6), 1045

(2014): Sin YH+, Nephrology (Carlton) 19 Suppl 3, 35

(2013): Berger M, J Allergy Clin Immunol Pract 1(6), 558

Venous thromboembolism 

(2017): Sanges S+, Autoimmun Rev 16(4), 377 [REVIEW]

Aseptic meningitis 

(2019): Waheed W+, Muscle Nerve Aug, Epub ahead of print (serious / 1 case)

(2017): Patel A+, S D Med 70(3), 119

(2017): Wanigasekera T+, Case Rep Transplant May, Epub

(2015): Mehta A+, Indian J Dermatol 60(3), 230 [REVIEW]

(2014): Nooraine J+, Neurol India 62(1), 98

(2012): Mullane D+, Ir Med J 105(6), 182

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Cerebral ischemia 

(2014): Chang T+, J Med Case Rep 8, 100

Chills 

(2017): Han JW, Korean Circ J 47(2), 179

(2017): Kaba S+, Eur Ann Allergy Clin Immunol 49(1), 11Pediatric

(2014): Lederer DJ+, PLoS One 9(8), Epub9%

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Encephalitis 

(2014): Nooraine J+, Neurol India 62(1), 98

Fever (pyrexia) 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

(2017): Alsina L+, Pharmacol Res Perspect 5(5), Epub

(2017): Han JW, Korean Circ J 47(2), 179

(2017): Hoffmann JHO+, J Dtsch Dermatol Ges 15(12), 1211

(2017): Kaba S+, Eur Ann Allergy Clin Immunol 49(1), 11Pediatric

(2017): Patel A+, S D Med 70(3), 119 (passim)

(2015): Vultaggio A+, Clin Drug Investig 35(3), 1792–5%

(2014): Dash CH+, PLoS One 9(6), Epub14%

(2014): Lederer DJ+, PLoS One 9(8), Epub18%

(2010): Donofrio PD+, Arch Neurol 67 (9), 1082

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

(1997): Benincasa P+, Ann Allergy Asthma Immunol 79(3), 189

Headache 

(2019): Belmokhtar C+, Neurol Ther March, Epub ahead of print

(2019): Waheed W+, Muscle Nerve Aug, Epub ahead of print12%

(2018): Hachulla E+, Biomed Res Int Mar, Epub

(2018): Song H+, Br J Dermatol 178(2), 363 [REVIEW]

(2017): Alsina L+, Pharmacol Res Perspect 5(5), Epub

(2017): Han JW, Korean Circ J 47(2), 179

(2017): Hoffmann JHO+, J Dtsch Dermatol Ges 15(12), 1211

(2017): Krivan G+, J Clin Immunol 37(6), 539

(2017): Patel A+, S D Med 70(3), 119 (passim)

(2017): Wietek S+, Hematology Oct, Epub ahead of print

(2016): Tavakolpour S, J Res Med Sci 21, 37 [REVIEW]

(2015): Thornby KA+, Ann Pharmacother 49(6), 715 [REVIEW]

(2014): Aubin F+, J Am Acad Dermatol 71(5), 94856% (moderate or severe)

(2014): Dash CH+, PLoS One 9(6), Epub29%

(2014): Lederer DJ+, PLoS One 9(8), Epub18%

(2013): Berger M, J Allergy Clin Immunol Pract 1(6), 558

(2012): Pintova S+, N Engl J Med 367(10), 974

(2010): Donofrio PD+, Arch Neurol 67 (9), 1082

(2010): Mitzel-Kaoukhov H+, Ann Allergy Asthma Immunol 104 (3), 253

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

(2003): Wittstock M+, Eur Neurol 50(3), 172 (mild)

Hyperthermia 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

Seizures 

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Shivering 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

Somnolence (drowsiness) 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

Stroke / cerebral infarction 

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Syncope / fainting 

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Vertigo / dizziness 

(2017): Wietek S+, Hematology Oct, Epub ahead of print

Dehydration  

(2014): Dash CH+, PLoS One 9(6), Epub6%

Abdominal pain 

(2014): Lederer DJ+, PLoS One 9(8), Epub9%

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Diarrhea 

(2015): Vultaggio A+, Clin Drug Investig 35(3), 179<5%

(2014): Dash CH+, PLoS One 9(6), Epub3%

Hepatitis 

(2012): Pintova S+, N Engl J Med 367(10), 974 Hepatitis C

Nausea 

(2018): Song H+, Br J Dermatol 178(2), 363 [REVIEW]

(2017): Han JW, Korean Circ J 47(2), 179

(2017): Hoffmann JHO+, J Dtsch Dermatol Ges 15(12), 1211

(2017): Patel A+, S D Med 70(3), 119 (passim)

(2017): Wietek S+, Hematology Oct, Epub ahead of print

(2016): Tavakolpour S, J Res Med Sci 21, 37 [REVIEW]

(2016): van Nimwegen JF+, Expert Opin Drug Saf 15(4), 513 [REVIEW]

(2015): Vultaggio A+, Clin Drug Investig 35(3), 179<2%

(2014): Dash CH+, PLoS One 9(6), Epub9%

(2014): Lederer DJ+, PLoS One 9(8), Epub9%

Vomiting  

(2014): Dash CH+, PLoS One 9(6), Epub17%

(2010): Donofrio PD+, Arch Neurol 67 (9), 1082

Urinary frequency  

(2014): Lederer DJ+, PLoS One 9(8), Epub9%

Anemia 

(2017): Yoon KL+, Korean Circ J 47(2), 209Pediatric

(2012): Pintova S+, N Engl J Med 367(10), 974

Cytopenia 

(2016): Kim NY+, Korean J Pediatr 59(Suppl 1), S60 [REVIEW]

Eosinophilia 

(2017): Yoon KL+, Korean Circ J 47(2), 209Pediatric

Hemolysis 

(2017): Akman AO+, Transfus Apher Sci 56(4), 531Pediatric

(2013): Berger M, J Allergy Clin Immunol Pract 1(6), 558

Hemolytic anemia 

(2018): Algaze SD+, BMJ Case Rep Mar, Epub (severe) (with nivolumab)

(2018): Liu X+, Ther Adv Neurol Disord 11, Epub2%

(2017): Tocan V+, J Pediatr Hematol Oncol 39(2), e100

(2016): Kim NY+, Korean J Pediatr 59(Suppl 1), S60 [REVIEW]

(2014): Tsukada H+, Ann Thorac Surg 97(6), 2175

Hemotoxicity 

(2016): Ammann EM+, Am J Hematol 91(6), 594 [REVIEW]

Thrombosis 

(2017): Agrawal Y+, Am J Ther 24(6), e689

(2012): Drelich DA+, Transfusion 52(10), 2075

(2012): Pintova S+, N Engl J Med 367(10), 974

Thrombotic microangiopathy 

(2014): Pan FF+, Transplant Proc 46(1), 278

Application-site pain 16%

(package insert)

Infusion-related reactions 

(2018): Liu X+, Ther Adv Neurol Disord 11, Epub

(2018): Ueda M+, Blood Rev 32(2), 106 [REVIEW]

(2015): Mehta A+, Indian J Dermatol 60(3), 230 [REVIEW]

(2014): Lederer DJ+, PLoS One 9(8), Epub9%

(2014): Quest GR+, Transfusion 54(12), 3088

(2013): Berger M, J Allergy Clin Immunol Pract 1(6), 558

Injection-site edema 

(2015): Vultaggio A+, Clin Drug Investig 35(3), 179

(2014): Arai H+, Psychogeriatrics 14(3), 165

Injection-site erythema 

(2015): Vultaggio A+, Clin Drug Investig 35(3), 179

(2014): Arai H+, Psychogeriatrics 14(3), 165

Injection-site exanthems 

(2014): Arai H+, Psychogeriatrics 14(3), 165

Injection-site pain 

(2015): Vultaggio A+, Clin Drug Investig 35(3), 179

Injection-site pruritus 

(2015): Vultaggio A+, Clin Drug Investig 35(3), 179

Injection-site reaction 

(2015): Vultaggio A+, Clin Drug Investig 35(3), 17914–20%

Arthralgia 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

(2017): Han JW, Korean Circ J 47(2), 179

(2014): Dash CH+, PLoS One 9(6), Epub6%

Asthenia / fatigue 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

(2017): Han JW, Korean Circ J 47(2), 179

(2017): Hoffmann JHO+, J Dtsch Dermatol Ges 15(12), 1211

(2017): Patel A+, S D Med 70(3), 119 (passim)

(1997): Benincasa P+, Ann Allergy Asthma Immunol 79(3), 189

Back pain 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

(2017): Wietek S+, Hematology Oct, Epub ahead of print

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Bone or joint pain 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

(2014): Lederer DJ+, PLoS One 9(8), Epub18%

Myalgia/Myositis/Myopathy/Myotoxicity (see also statin-induced necrotizing autoimmune myopathy) 

(2018): Hachulla E+, Biomed Res Int Mar, Epub

(2017): Han JW, Korean Circ J 47(2), 179

(2017): Patel A+, S D Med 70(3), 119 (passim)

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Neck rigidity 

(2014): Lederer DJ+, PLoS One 9(8), Epub18%

Ocular hemorrhage 

(2014): Lederer DJ+, PLoS One 9(8), Epub9%

Nephrotoxicity / kidney injury / acute kidney injury (AKI) / drug-induced kidney injury 

(2014): Lederer DJ+, PLoS One 9(8), Epub9%

(2013): Berger M, J Allergy Clin Immunol Pract 1(6), 558

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

(2004): Orbach H+, Semin Arthritis Rheum 34(3), 593 [REVIEW] (from sucrose)

(2000): Dilhuydy MS+, Presse Med 29(17), 942

(2000): Levy JB+, QJM 93(11), 7517%

Renal failure 

(2017): Hoffmann JHO+, J Dtsch Dermatol Ges 15(12), 1211

(2013): Berger M, J Allergy Clin Immunol Pract 1(6), 558

(2010): Graumann A+, Postgrad Med 122 (2), 142 (acute)

Cough 

(2014): Lederer DJ+, PLoS One 9(8), 18%

(1997): Benincasa P+, Ann Allergy Asthma Immunol 79(3), 189

Dyspnea / shortness of breath 

(2014): Lederer DJ+, PLoS One 9(8), Epub9%

(2014): Quest GR+, Transfusion 54(12), 3088 (transfusion-related)

Nasopharyngitis 

(2014): Arai H+, Psychogeriatrics 14(3), 165

Pulmonary embolism 

(2013): Hahn AF+, J Peripher Nerv Syst 18(4), 321 (1 case)

(2010): Donofrio PD+, Arch Neurol 67 (9), 1082

Pulmonary toxicity 

(2014): Quest GR+, Transfusion 54(12), 3088 (transfusion-related)

Rhinitis 

(2007): Fernandez AP+, Dermatol Ther 20(4), 288 (passim)

Adverse effects 

(2019): Waheed W+, Muscle Nerve Aug , Epub ahead of print17% (<1% serious)

(2017): Tang-Wai R+, Seizure 47, 34 (2 cases)Pediatric

(2016): Frenzel W+, Int J Clin Pharmacol Ther 54(11), 8471%

(2015): Bachelet T+, Clin Transplant 29(5), 439 (with rituximab)

(2014): Saeedian M+, Int Arch Allergy Immunol 164(2), 151 [REVIEW]

(2014): Vo AA+, Transplantation 98(3), 312 (serious / 5 cases) (with rituximab)

(2014): Warnatz K+, Clin Exp Immunol 178 Suppl 1, 139

(2013): Berger M, J Allergy Clin Immunol Pract 1(6), 558

(2013): Eftimov F+, Cochrane Database Syst Rev 12, CD001797 [REVIEW]

(2013): Hahn AF+, J Peripher Nerv Syst 18(4), 321



Adverse reactions attributed to entire drug class Covid-19 putative drug

Cardiovascular adverse effect 

(2020): Carpenter A+, Front Cardiovasc Med 7, 85 [REVIEW]

(2020): Giudicessi JR+, Mayo Clin Proc May, Online ahead of print [REVIEW]

(2020): Naksuk N+, Eur Heart J Acute Cardiovasc Care May, Epub ahead of print [REVIEW]

(2020): Sarayani A+, Res Social Adm Pharm Apr, Epub ahead of print [REVIEW]

(2020): Zhang D+, Zhongguo Zhong Yao Za Zhi (Chinese) 45(10), 2275-2286 [REVIEW]

Neuropsychiatric / neuropsychological adverse effect 

(2021): Borah P+, Front Mol Biosci 8, 627723

(2020): García CAC+, Gen Hosp Psychiatry Jun, Online ahead of print [REVIEW]

Gastrointestinal disorder / discomfort 

(2020): Sun J+, Clin Pharmacol Ther Apr, Epub ahead of print23%

Thrombocytopenia 

(2020): Nham E+, Infect Chemother Apr, Epub ahead of print

Adverse effects 

(2021): Bérard A+, PLoS One 16(5), e0251746 [REVIEW] (in pregnancy)

(2021): Cheng Q+, Aging (Albany NY) Sep, Online ahead of print [REVIEW]

(2021): Cruciani F+, Recenti Prog Med 112(3), 195-206 [REVIEW]

(2021): Ommati MM+, J Biochem Mol Toxicol May, Online ahead of print [REVIEW]

(2021): Qiu R+, Medicine (Baltimore) 100(16), e25532 [REVIEW]

(2021): Wu SS+, Chin Med J (Engl) Jul, Online ahead of print [REVIEW]

(2020): Favilli A+, J Matern Fetal Neonatal Med Jun, Online ahead of print [REVIEW]

(2020): Griffiths G+, Trials 21(1), 544

(2020): Patil VM+, Life Sci May, Epub ahead of print [REVIEW]

(2020): Rhodes NJ+, medRxiv Jun, Preprint

(2020): Sun J+, Clin Pharmacol Ther Apr, Epub ahead of print38%

(2020): Svensson M, Lakartidningen (Swedish) Apr, 117

(2020): Wen CY+, Zhonghua Nei Ke Za Zhi (Chinese) May, Epub ahead of print

(2020): Zekarias A+, Drug Saf Sep, Online ahead of print [REVIEW]

(2020): Zhong H+, Pharmacol Res Apr, Epub ahead of print [REVIEW]

Adverse reactions attributed to entire drug class Immunomodulator

Page last updated 08/02/2021

Drug Eruption Mobile Site

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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