Naltrexone has the capacity to cause hepatocellular injury when given in excessive doses.

Troxyca is naltrexone and oxycodone.

Contra-indicated in acute hepatitis or liver failure; patients receiving opioid analgesics, with current physiologic opioid dependence, or in acute opioid withdrawal.

Contrave, a combination of naltrexone and bupropion, has been approved by the FDA for chronic weight management.