Kidney toxicity was observed in animals who received viltolarsen. Although kidney toxicity was not observed in the clinical studies with viltolarsen, the clinical experience with viltolarsen is limited, and kidney toxicity, including potentially fatal glomerulonephritis, has been observed after administration of some antisense oligonucleotides. Kidney function should be monitored in patients taking viltolarsen.
- TRADE NAME: Viltepso (Nippon Shinyaku)
- INDICATIONS: Duchenne muscular dystrophy
- CLASS: Antisense oligomer, Antisense oligonucleotide
- HALF-LIFE: 2.5 hours
- FDA APPROVAL DATE: 08/12/2020
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Based on in vitro data, viltolarsen has a low potential for drug-drug interactions with major CYP enzymes and drug transporters in humans. - PREGNANCY: No human or animal data available to assess use during pregnancy.
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Page last updated 07/31/2023
