Antidiabetic. Treatment of type 2 diabetes mellitus.
Adjunct for the treatment of obesity and for weight loss management in defined populations and health conditions.
Not indicated for use in type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
Semaglutide causes a delay of gastric emptying, and thereby has the potential to impact the absorption of concomitantly administered oral medications.
An oral formulation of semaglutide and sodium salcaprozate (an intestinal permeation enhancer) is available in the United States and Europe.
WARNING: RISK OF THYROID C-CELL TUMORS
IN RODENTS, SEMAGLUTIDE CAUSES THYROID C-CELL TUMORS. IT IS UNKNOWN WHETHER SEMAGLUTIDE CAUSES THYROID C-CELL TUMORS, INCLUDING MEDULLARY THYROID CARCINOMA (MTC), IN HUMANS AS THE HUMAN RELEVANCE OF SEMAGLUTIDE-INDUCED RODENT THYROID C-CELL TUMORS HAS NOT BEEN DETERMINED. SEMAGLUTIDE IS CONTRAINDICATED IN PATIENTS WITH A PERSONAL OR FAMILY HISTORY OF MTC OR IN PATIENTS WITH MULTIPLE ENDOCRINE NEOPLASIA SYNDROME TYPE 2. COUNSEL PATIENTS REGARDING THE POTENTIAL RISK OF MTC AND SYMPTOMS OF THYROID TUMORS.
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Click on the DRUG REVIEW ARTICLE links (above) to see two reviews of semaglutide in the Taylor & Francis journal Expert Opinion on Drug Safety.
(Note that non-subscribers to the journal will only be able to see an abstract of the article.)
Page last updated 07/07/2025
