Summary for Lorlatinib


Breastfeeding
  • Trade Name: Lorbrena (Pfizer)
  • Indications:

    indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) whose disease has progressed on:

    crizotinib and at least one other ALK inhibitor for metastatic disease;

    or alectinib as the first ALK inhibitor therapy for metastatic disease;

    or ceritinib as the first ALK inhibitor therapy for metastatic disease.


  • Class: Anaplastic lymphoma kinase (ALK) inhibitor, Kinase inhibitor
  • Half-life: 24 hours
  • FDA Approval Date: 11/02/2018
  • Clinically important, potentially hazardous interactions with:
    Rifampin
  • Pregnancy: can cause embryo-fetal harm

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Page last updated 02/10/2026

Symbol key

Incidence - Help

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Seriousness - Help

Hospitalization possible
Life threatening
Fatal

Warnings in other populations - Help

BreastfeedingBreast feeding

GeriatricGeriatric

PediatricPediatric